Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
Hongjie Li(Howard Hughes Medical Institute), Jasper Janssens(VIB-KU Leuven Center for Cancer Biology), Maxime De Waegeneer(VIB-KU Leuven Center for Cancer Biology), Sai Saroja Kolluru(Chan Zuckerberg Initiative (United States)), Kristofer Davie(VIB-KU Leuven Center for Brain & Disease Research), Vincent Gardeux(SIB Swiss Institute of Bioinformatics), Wouter Saelens(SIB Swiss Institute of Bioinformatics), Fabrice David(SIB Swiss Institute of Bioinformatics), Maria Brbić(Chan Zuckerberg Initiative (United States)), Katina I. Spanier(VIB-KU Leuven Center for Cancer Biology), Jure Leskovec(Chan Zuckerberg Initiative (United States)), Colleen N. McLaughlin(Howard Hughes Medical Institute), Qijing Xie(Howard Hughes Medical Institute), Robert C. Jones(Chan Zuckerberg Initiative (United States)), Katja Brueckner(University of California, San Francisco), Jiwon Shim(Hanyang University), Sudhir Gopal Tattikota(Howard Hughes Medical Institute), Frank Schnorrer(Centre National de la Recherche Scientifique), Katja Rust(Philipps University of Marburg), Todd Nystul(University of California, San Francisco), Zita Carvalho-Santos(Champalimaud Foundation), Carlos Ribeiro(Champalimaud Foundation), Soumitra Pal(National Institutes of Health), Sharvani Mahadevaraju(National Institutes of Health), Teresa M. Przytycka(National Institutes of Health), Aaron M. Allen(University of Oxford), Stephen F. Goodwin(University of Oxford), Cameron W. Berry(Stanford University), Margaret T. Fuller(Stanford University), Helen White‐Cooper(Cardiff University), Erika Matunis(Johns Hopkins University), Stephen DiNardo(California Institute for Regenerative Medicine), Anthony Galenza(Stanford University), Lucy Erin O’Brien(Stanford University), Julian A. T. Dow(University of Glasgow), Heinrich Jasper(Sunesis (United States)), Brian Oliver(National Institutes of Health), Norbert Perrimon(Howard Hughes Medical Institute), Bart Deplancke(SIB Swiss Institute of Bioinformatics), Stephen R. Quake(Chan Zuckerberg Initiative (United States)), Liqun Luo(Howard Hughes Medical Institute), Stein Aerts(VIB-KU Leuven Center for Cancer Biology), Devika Agarwal(John Radcliffe Hospital), Yasir H. Ahmed-Braimah(Syracuse University), Michelle N Arbeitman(Florida State University), Majd Ariss(Harvard University), Jordan Augsburger(University of California, San Francisco), Kumar Ayush(Stanford University), Catherine C. Baker(Stanford University), Torsten U. Banisch(NYU Langone Health), Katja Birker(Philipps University of Marburg), Rolf Bodmer(Sanford Burnham Prebys Medical Discovery Institute), Benjamin Bolival(Stanford University), Susanna E. Brantley(Stanford University), Julie A. Brill(University of Toronto), Nora C. Brown(Cornell University), Norene A. Buehner(Cornell University), Xiaoyu Cai(Sunesis (United States)), Rita Cardoso-Figueiredo(Champalimaud Foundation), Fernando Casares(Centro Andaluz de Biología del Desarrollo), Amy K. Chang(University of California, Berkeley), Thomas R. Clandinin(Stanford University), Sheela Crasta(Chan Zuckerberg Initiative (United States)), Claude Desplan(New York University), Angela M. Detweiler(Chan Zuckerberg Initiative (United States)), Darshan B. Dhakan(Champalimaud Foundation), Erika Doná(Johns Hopkins University), Stefanie Engert(University of California, Berkeley), Swann Floc’hlay(VIB-KU Leuven Center for Cancer Biology), Nancy George(European Bioinformatics Institute), Amanda J. González-Segarra(University of California, Berkeley), Andrew K. Groves(Baylor College of Medicine), Samantha C. Gumbin(Stanford University), Yanmeng Guo(Howard Hughes Medical Institute), D. Harris(Stanford University), Yael Heifetz(Hebrew University of Jerusalem), Stephen L Holtz(Harvard University), Felix Horns(Stanford University), Bruno Hudry(Centre National de la Recherche Scientifique), Ruei‐Jiun Hung(Harvard University), Yuh Nung Jan(Howard Hughes Medical Institute), Jacob S Jaszczak(Howard Hughes Medical Institute), Gregory S.X.E. Jefferis(MRC Laboratory of Molecular Biology), Jim Karkanias(Chan Zuckerberg Initiative (United States)), Timothy L. Karr(Arizona State University), Nadja Sandra Katheder(Sunesis (United States)), James Kezos(Sanford Burnham Prebys Medical Discovery Institute), Anna Kim(Uppsala University), Seung K. Kim(Stanford University), Lutz Kockel(Stanford University), Νικόλαος Κωνσταντινίδης(Université Paris Cité), Thomas B. Kornberg(University of California, San Francisco), Henry M. Krause(University of Toronto), Andrew Thomas Labott(Stanford University), Meghan Laturney(University of California, Berkeley), Ruth Lehmann(NYU Langone Health), Sarah G. Leinwand(University of California, Berkeley), Jun Li(Howard Hughes Medical Institute), Joshua Shing Shun Li(Howard Hughes Medical Institute), Kai Li(Howard Hughes Medical Institute), Ke Li(Howard Hughes Medical Institute), Liying Li(Howard Hughes Medical Institute), Tun Li(Howard Hughes Medical Institute), Maria Litovchenko(SIB Swiss Institute of Bioinformatics), Han-Hsuan Liu(Howard Hughes Medical Institute), Yifang Liu(Harvard University), Tzu‐Chiao Lu(Howard Hughes Medical Institute), Jonathan Manning(European Bioinformatics Institute), Anjeli Mase(University of California, San Francisco), Mikaela Matera-Vatnick(Cornell University), Neuza R. Matias(Stanford University), Caitlin E. McDonough-Goldstein(University of Vienna), Aaron McGeever(University of Oxford), Alex McLachlan(University of Cambridge), Paola Moreno-Roman(Stanford University), Norma Neff(Chan Zuckerberg Initiative (United States)), Megan C. Neville(University of Oxford), Sang Ngo(Stanford University), Tanja Nielsen(Sanford Burnham Prebys Medical Discovery Institute), Caitlin E. O’Brien(Howard Hughes Medical Institute), David Osumi-Sutherland(European Bioinformatics Institute), Mehmet Neset Özel(New York University), Irene Papatheodorou(European Bioinformatics Institute), Maja Petković(Howard Hughes Medical Institute), Clare Pilgrim(University of Cambridge), Angela Oliveira Pisco(Chan Zuckerberg Initiative (United States)), Carolina E. Reisenman(University of California, Berkeley), Erin Sanders(Stanford University), Gilberto dos Santos(Harvard University), Kristin Scott(University of California, Berkeley), Aparna Sherlekar(Stanford University), Philip K. Shiu(University of California, Berkeley), David Sims(John Radcliffe Hospital), Rene Sit(Chan Zuckerberg Initiative (United States)), Maija Slaidina(New York University), Harold E. Smith(National Institutes of Health), Gabriella R Sterne(University of California, Berkeley), Yu‐Han Su(Howard Hughes Medical Institute), Daniel Sutton(Baylor Genetics), Marco Tamayo(Sanford Burnham Prebys Medical Discovery Institute), Michelle Tan(Chan Zuckerberg Initiative (United States)), Ibrahim Tastekin(Champalimaud Foundation), Christoph D. Treiber(Mansfield University), David Vacek(Howard Hughes Medical Institute), Georg Vogler(Sanford Burnham Prebys Medical Discovery Institute), Scott Waddell(Mansfield University), Wanpeng Wang(University of California, San Francisco), Rachel I. Wilson(Harvard University), Mariana F. Wolfner(Cornell University), Yiu-Cheung E. Wong(Stanford University), Anthony Xie(Howard Hughes Medical Institute), Jun Xu(Harvard University), Shinya Yamamoto(Baylor College of Medicine), Yan Jia(Chan Zuckerberg Initiative (United States)), Zepeng Yao(University of California, Berkeley), Kazuki Yoda(Stanford University), Ruijun Zhu(Howard Hughes Medical Institute), Robert P. Zinzen(Max Delbrück Center)
Cited by 837Open Access
Abstract
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type–related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
Related Papers
No related papers found
Powered by citation graph analysis