The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Geert J.L.H. van Leenders, Theodorus van der Kwast(Princess Margaret Cancer Centre), David J. Grignon(Indiana University School of Medicine), Andrew Evans(University Health Network), Glen Kristiansen(University Hospital Bonn), Charlotte F. Kweldam, Geert Litjens(Radboud University Nijmegen), Jesse K. McKenney(Cleveland Clinic), Jonathan Melamed(NYU Langone Health), N. Mottet(Emergency University), Gladell P. Paner(University Health Network), Hemamali Samaratunga(The University of Queensland), Ivo G. Schoots(Radboud University Nijmegen), Jeffry Simko(University of California, San Francisco), Toyonori Tsuzuki(Aichi Medical University), Murali Varma(University Hospital of Wales), Anne Y. Warren(Cambridge University Hospitals NHS Foundation Trust), Thomas M. Wheeler(University Health Network), Sean R. Williamson(Henry Ford Health System), Kenneth A. Iczkowski(Radboud University Nijmegen)
The American Journal of Surgical Pathology
May 26, 2020
10.1097/pas.0000000000001497
Cited by 676Open Access
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Abstract

Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging-targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.

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