<i>Fusobacterium nucleatum</i> promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
Ying Zhang(Sir Run Run Shaw Hospital), Lu Zhang(Sir Run Run Shaw Hospital), Sheng Zheng(Zhejiang Cancer Hospital), Mengjie Li(Sir Run Run Shaw Hospital), Chaochao Xu(Sir Run Run Shaw Hospital), Dingjiacheng Jia(Zhejiang Cancer Hospital), Yadong Qi(Sir Run Run Shaw Hospital), Tongyao Hou(Sir Run Run Shaw Hospital), Lan Wang(Sir Run Run Shaw Hospital), Boya Wang(Sir Run Run Shaw Hospital), Aiqing Li(Sir Run Run Shaw Hospital), Shujie Chen(Sir Run Run Shaw Hospital), Jianmin Si(Sir Run Run Shaw Hospital), Wei Zhuo(Sir Run Run Shaw Hospital)
Cited by 192Open Access
Abstract
in tumor tissues of CRC patients was positively associated with the expression levels of ALPK1 and ICAM1. Moreover, high expression of ALPK1 or ICAM1 was significantly associated with a shorter overall survival time of CRC patients. This study provides a new insight into the role of gut microbiota in engaging into the distant metastasis of CRC cells.
Related Papers
No related papers found
Powered by citation graph analysis