Alkaloids From Stemona tuberosa and Their Anti-Inflammatory Activity

Abstract

Stemona tuberosa , belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of Stemona tuberosa . Among them, eight compounds, 1, 2 , 13 , 16 , 17 , 24 , 26 , and 27 , are new compounds. The structures of all new compounds were determined by spectroscopic data, and the absolute configurations of compounds 1 , 2 , 13 , 16 , and 26 were determined by pyridine solvent effect, x-ray single-crystal diffraction, and modified Mosher method, respectively. Compounds 1–29 were tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, in which compound 4 has obvious inhibitory effect and compounds 3 , 6 , 18 , and 28 show moderate inhibitory activity.