Drugging the Next Undruggable KRAS Allele-Gly12Asp
Qinheng Zheng(Howard Hughes Medical Institute), D. Matthew Peacock(Howard Hughes Medical Institute), Kevan M. Shokat(Howard Hughes Medical Institute)
Cited by 38Open Access
Abstract
Since its discovery as the first human oncogene in 1983, the small GTPase KRAS has been a major target of cancer drug discovery. The paper reported in this issue describes a long-awaited small molecule drug candidate of the oncogenic KRAS (G12D) mutant for the treatment of currently incurable pancreatic cancer.
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