Ghrelin

Timo D. Müller(Helmholtz Zentrum München), Rubén Nogueiras(Universidade de Santiago de Compostela), Mark L. Andermann(Beth Israel Deaconess Medical Center), Zane B. Andrews(Monash University), Stefan D. Anker(Charité - Universitätsmedizin Berlin), Jesús Argente(Instituto de Salud Carlos III), Rachel L. Batterham(University College London), S.C. Benoit(University of Cincinnati Medical Center), C. Y. Bowers(Tulane University), Fabio Broglio(University of Turin), Felipe F. Casanueva(Complejo Hospitalario Universitario de Santiago), David A. D’Alessio(Duke University), Inge Depoortere(KU Leuven), Allan Geliebter(St. Luke's-Roosevelt Hospital Center), Ezio Ghigo(Johns Hopkins Medicine), Philip A. Cole(Monash University), Michael A. Cowley(Monash University), D. E. Cummings(University of Washington), Alain Dagher(McGill University), Sabrina Diano(Yale University), Suzanne L. Dickson(University of Gothenburg), Carlos Diéguez(University of Washington), Riccarda Granata(University of Turin), Harvey J. Grill(University of Pennsylvania), Kelly Grove(Charité - Universitätsmedizin Berlin), Kirk M. Habegger(University of Alabama at Birmingham), Kristy M. Heppner(Charité - Universitätsmedizin Berlin), Mark L. Heiman(Beth Israel Deaconess Medical Center), Laura M. Holsen(Monash University), Birgitte Holst(University of Copenhagen), Akio Inui(Kagoshima University), J-O Jansson(University of Gothenburg), Henriette Kirchner(University Hospital Schleswig-Holstein), Márta Korbonits(University of Washington), Blandine Laferrère(Columbia University), C.W. LeRoux(University College Dublin), Miguel López(Universidade de Santiago de Compostela), Sophie Morin(Helmholtz Zentrum München), Michiko Nakazato(University of Miyazaki), Ralf Nass(McGill University), Diego Pérez–Tilve(Yale University), Paul T. Pfluger(Helmholtz Zentrum München), Thue W. Schwartz(University of Copenhagen), Randy J. Seeley(University of Michigan–Ann Arbor), Mark W. Sleeman(Monash University), Yuxiang Sun(Monash University), Lori Sussel(Monash University), Jenny Tong(Duke University), Michael O. Thorner(University of Virginia), A. J. van der Lely(Erasmus University Rotterdam), L. H. T. Van der Ploeg(Jazz Pharmaceuticals (United States)), Jeffrey M. Zigman, Masayasu Kojima(University of Washington), Kenji Kangawa(Charité - Universitätsmedizin Berlin), R G Smith(Hospital Infantil Universitario Niño Jesús), Tamás L. Horváth(Columbia University), M. Tschöp(Helmholtz Zentrum München)
Molecular Metabolism
April 7, 2015
10.1016/j.molmet.2015.03.005
Cited by 1,001Open Access
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Abstract

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

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