Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
Asier Fernández-Pato(University Medical Center Groningen), Ana Virseda‐Berdices(Instituto de Salud Carlos III), Salvador Resino(Instituto de Salud Carlos III), Pablo Ryan(Universidad Complutense de Madrid), Óscar Martínez-Nieto(Hospital Universitario del Tajo), Felipe Pérez‐García(Universidad de Alcalá), María Martin‐Vicente(Instituto de Salud Carlos III), Daniel Valle‐Millares(Instituto de Salud Carlos III), Oscar Brochado‐Kith(Instituto de Salud Carlos III), Rafael Blancas(Hospital Universitario del Tajo), Amalia Martínez(Hospital Universitario Infanta Leonor), Francisco C. Ceballos(Instituto de Salud Carlos III), Sofía Bartolomé‐Sanchez(Instituto de Salud Carlos III), Erick Joan Vidal-Alcántara(Instituto de Salud Carlos III), David Alonso(Hospital Universitario Príncipe de Asturias), Natalia Blanca‐López(Hospital Universitario Infanta Leonor), Ignacio Ramirez Martinez-Acitores(Hospital Universitario del Tajo), Laura Martín‐Pedraza(Hospital Universitario Infanta Leonor), María Ángeles Jiménez‐Sousa(Instituto de Salud Carlos III), Amanda Fernández‐Rodríguez(Instituto de Salud Carlos III)
Cited by 92Open Access
Abstract
BACKGROUND: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. METHODS AND RESULTS: = 0.042). CONCLUSIONS: SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality.
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