Notch-Regulated c-Kit–Positive Liver Sinusoidal Endothelial Cells Contribute to Liver Zonation and Regeneration

Juanli Duan; Ziyi Zhou; Bai Ruan; Zhiqiang Fang; Jian Ding; Jingjing Liu; Ping Song; Hao Xu; Xu Chen; Zhen‐Sheng Yue; Hua Han; Guo‐Rui Dou; Lin Wang

doi:10.1016/j.jcmgh.2022.01.019

Notch-Regulated c-Kit–Positive Liver Sinusoidal Endothelial Cells Contribute to Liver Zonation and Regeneration

Juanli Duan, Ziyi Zhou, Bai Ruan(State Key Laboratory of Cancer Biology), Zhiqiang Fang, Jian Ding, Jingjing Liu, Ping Song, Hao Xu, Xu Chen, Zhen‐Sheng Yue(First Hospital of Xi'an), Hua Han(Xi’an University), Guo‐Rui Dou(China XD Group (China)), Lin Wang(Xi'an University of Technology)

Cellular and Molecular Gastroenterology and Hepatology

January 1, 2022

10.1016/j.jcmgh.2022.01.019

Cited by 39Open Access

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Abstract

BACKGROUND & AIMS: SECs, a newly identified subset of SECs in liver regeneration. METHODS: or quantitative polymerase chain reaction injection. RESULTS: SEC infusion attenuates toxin-induced liver injuries in mice. CONCLUSIONS: SECs contributes to liver zonation and regeneration through Wnt2 and is regulated by Notch signaling, providing opportunities for novel therapeutic approaches to liver injury in the future. Transcript profiling: GEO (accession number: GSE134037).

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