Chemotherapy in advanced ovarian cancer: an overview of randomised clinical trials. Advanced Ovarian Cancer Trialists Group.

Lesley Stewart; Kristian Aabo; P I Adnitt; Malcolm Adams; Susanne Alberts; V. Barley; David Bell; Umberto Bianchi; John A. Blessing; Marc Buyse; Giorgio Bolis; S. Brodovsky; Howard W. Bruckner; Renzo Canetta; V Chylak; Joshua M. Cohen; Nicoletta Colombo; Francesco Conte; D. Crowther; F De Oliveira; J Edmonson; E Gilbey; Stan B. Kaye; Adam G. Laing; Fabio Landoni; Robert Leonard; Craig Lewis; Yun Liu; C. Mangioni; Silvia Marsoni; H.G. Meerpohl; Ulrich Müller; G Omura; Kanak Parmar; J Pater; S. Pecorelli; M. Presti; Willi Sauerbrei; R V Smalley; J.R. Solomon; Jeremy Sturgeon; Hannah L. Tattersall; John Wharton; W. E. Tjon a Ten; Bokkel Huinink; M. Tomirotti; Valter Torri; Claes G. Tropé; Marvin Turbow; Jan B. Vermorken; Mason Webb; W. John Wilbur; John Williams; Ctx Cbdsa; Cacp; D Parkin; E Laara; C Muir; R Young; B Chabner; S Hubbard; E Wiltshaw; T Kroner; C Williams; K Stevensen; R Buchanan; C Williams; G Mead; A Arnold; G Bolis; G Bortolozzi; G Carinelli; K Bertelsen; J Jakobsen; J Andersen; G Omura; B Bundy; J Berek; S Curry; G Delgado; R Mortel; S Hubbard; P Barker; R Young; Gruppo Interegionale; Cooperativo Oncologico; Ginecologia; M Tomirotti; S Perrone; P Gie; S Marsoni; Torri Taiana; A; R Simes; K Aabo; I Hald; S Horbov; H Brodovsky; M Bauer; J Horton; P Elson; H Bruckner; M Pagano; G Falkson; V Chylak; K Kolaric; K Krusic; J Edmonson; T Flemming; D Decker; A Miller; D Klaassen; D Boyes; Medical Research; Council Working; Party On; Ovarian Cancer; G Omura; C Morrow; J Blessing; R Park; J Blom; P Disaia; L Lagasse; J Blessing; Jfg Sturgeon; S Fine; M Gospodarowicz; C Trope; M Turbow; H Jones; V Yu; B Greenberg; J Hannigan; F Torti; J Wharton; C Edwards; F Rutledge; D Bell; R Woods; J Levi; R Fox; Mhn Tattersall; Gynaecological Group; ; Sydney Branch; Ludwig Institute For; Cancer Research; D Decker; M Thomas; R Fleming; R Leonard; G Smart; Jrb Livingston; J Masding; T Sarkar; J White; D Wilbur; R Rentschler; R Wagner; E Keeney; A King; D Hilliard; C Williams; G Mead; F Macbeth; S Vogl; B Kaplan; M Pagano; De Oliveira; C Lacave; A Villani; C; G Omura; J Blessing; C Ehrlich; C Cohen; J Goldberg; J Holland; E Wiltshaw; B Evans; Rustin Gilbev; E Baker; J Barker; G; M Adams; I Kerby; I Rocker; A Evans; K Johansen; C Franks; C Mangioni; G Bolis; S Pecorelli; E Wiltshaw; B Evans; S Harland; D Alberts; S Green; E Hannigan; H Anderson; J Wagstaff; D Crowther; A Evans; K Johansen; C Franks; P Conte; M Bruzzone; F Carnino; J Edmonson; G Mccormack; H Wieand; T Kato; H Nishimura; T Yamabe; J Pater; Bokkel Ten; W Huinink; M Van Der Burg; A Van Oosterom; M Adams; K Johansen; K James; I Rocker; J Barlow; S Lele; U Emrich; J Carmo-Pereira; Oliveira Costa; F Henriques; E; Almneida Ricardo; J; G Delgado; F Smith; E Mclaughlin; N Tuholski; H Senn; D Lei; A Castano-Almendral; J Carmo-Pereira; Oliveira Costa; F Henriques; E; H Harvey; A Lipton; M Simmonds; A Calvert; D Newell; L Gumbrell; C: Turbow; M; Kaye

doi:10.1136/bmj.303.6807.884

Chemotherapy in advanced ovarian cancer: an overview of randomised clinical trials. Advanced Ovarian Cancer Trialists Group.

Lesley Stewart(SWOG Cancer Research Network), Kristian Aabo(Eastern Cooperative Oncology Group), P I Adnitt(Gynecologic Oncology Group), Malcolm Adams(Gynecologic Oncology Group), Susanne Alberts(Australia New Zealand Gynaecological Oncology Group), V. Barley(SWOG Cancer Research Network), David Bell(Eastern Cooperative Oncology Group), Umberto Bianchi(Gynecologic Oncology Group), John A. Blessing(Eastern Cooperative Oncology Group), Marc Buyse(Gynecologic Oncology Group), Giorgio Bolis(Australia New Zealand Gynaecological Oncology Group), S. Brodovsky(Eastern Cooperative Oncology Group), Howard W. Bruckner(Australia New Zealand Gynaecological Oncology Group), Renzo Canetta(Clinical Oncological Society of Australia), V Chylak(SWOG Cancer Research Network), Joshua M. Cohen(Clinical Oncological Society of Australia), Nicoletta Colombo(SWOG Cancer Research Network), Francesco Conte(Gynecologic Oncology Group), D. Crowther(Clinical Oncological Society of Australia), F De Oliveira(Gynecologic Oncology Group), J Edmonson(Australia New Zealand Gynaecological Oncology Group), E Gilbey(Australia New Zealand Gynaecological Oncology Group), Stan B. Kaye(Australia New Zealand Gynaecological Oncology Group), Adam G. Laing(Australia New Zealand Gynaecological Oncology Group), Fabio Landoni(Clinical Oncological Society of Australia), Robert Leonard(Australia New Zealand Gynaecological Oncology Group), Craig Lewis(Eastern Cooperative Oncology Group), Yun Liu(Gynecologic Oncology Group), C. Mangioni(Clinical Oncological Society of Australia), Silvia Marsoni(SWOG Cancer Research Network), H.G. Meerpohl(Gynecologic Oncology Group), Ulrich Müller(Clinical Oncological Society of Australia), G Omura(Australia New Zealand Gynaecological Oncology Group), Kanak Parmar(Clinical Oncological Society of Australia), J Pater(Australia New Zealand Gynaecological Oncology Group), S. Pecorelli(Clinical Oncological Society of Australia), M. Presti(Australia New Zealand Gynaecological Oncology Group), Willi Sauerbrei(Australia New Zealand Gynaecological Oncology Group), R V Smalley(Australia New Zealand Gynaecological Oncology Group), J.R. Solomon(Gynecologic Oncology Group), Jeremy Sturgeon(Gynecologic Oncology Group), Hannah L. Tattersall(Eastern Cooperative Oncology Group), John Wharton(Clinical Oncological Society of Australia), W. E. Tjon a Ten(Australia New Zealand Gynaecological Oncology Group), Bokkel Huinink(Clinical Oncological Society of Australia), M. Tomirotti(Clinical Oncological Society of Australia), Valter Torri(Eastern Cooperative Oncology Group), Claes G. Tropé(Gynecologic Oncology Group), Marvin Turbow(Eastern Cooperative Oncology Group), Jan B. Vermorken(Gynecologic Oncology Group), Mason Webb(Eastern Cooperative Oncology Group), W. John Wilbur(Australia New Zealand Gynaecological Oncology Group), John Williams(Clinical Oncological Society of Australia), Ctx Cbdsa(Clinical Oncological Society of Australia), Cacp, D Parkin, E Laara, C Muir, R Young, B Chabner, S Hubbard, E Wiltshaw, T Kroner, C Williams, K Stevensen, R Buchanan, C Williams, G Mead, A Arnold, G Bolis, G Bortolozzi, G Carinelli, K Bertelsen, J Jakobsen, J Andersen, G Omura, B Bundy, J Berek, S Curry, G Delgado, R Mortel, S Hubbard, P Barker, R Young, Gruppo Interegionale, Cooperativo Oncologico, Ginecologia, M Tomirotti, S Perrone, P Gie, S Marsoni, Torri Taiana, A, R Simes, K Aabo, I Hald, S Horbov, H Brodovsky, M Bauer, J Horton, P Elson, H Bruckner, M Pagano, G Falkson, V Chylak, K Kolaric, K Krusic, J Edmonson, T Flemming, D Decker, A Miller, D Klaassen, D Boyes, Medical Research, Council Working, Party On, Ovarian Cancer, G Omura, C Morrow, J Blessing, R Park, J Blom, P Disaia, L Lagasse, J Blessing, Jfg Sturgeon, S Fine, M Gospodarowicz, C Trope, M Turbow, H Jones, V Yu, B Greenberg, J Hannigan, F Torti, J Wharton, C Edwards, F Rutledge, D Bell, R Woods, J Levi, R Fox, Mhn Tattersall, Gynaecological Group, ; Sydney Branch, Ludwig Institute For, Cancer Research, D Decker, M Thomas, R Fleming, R Leonard, G Smart, Jrb Livingston, J Masding, T Sarkar, J White, D Wilbur, R Rentschler, R Wagner, E Keeney, A King, D Hilliard, C Williams, G Mead, F Macbeth, S Vogl, B Kaplan, M Pagano, De Oliveira, C Lacave, A Villani, C, G Omura, J Blessing, C Ehrlich, C Cohen, J Goldberg, J Holland, E Wiltshaw, B Evans, Rustin Gilbev, E Baker, J Barker, G, M Adams, I Kerby, I Rocker, A Evans, K Johansen, C Franks, C Mangioni, G Bolis, S Pecorelli, E Wiltshaw, B Evans, S Harland, D Alberts, S Green, E Hannigan, H Anderson, J Wagstaff, D Crowther, A Evans, K Johansen, C Franks, P Conte, M Bruzzone, F Carnino, J Edmonson, G Mccormack, H Wieand, T Kato, H Nishimura, T Yamabe, J Pater, Bokkel Ten, W Huinink, M Van Der Burg, A Van Oosterom, M Adams, K Johansen, K James, I Rocker, J Barlow, S Lele, U Emrich, J Carmo-Pereira, Oliveira Costa, F Henriques, E, Almneida Ricardo, J, G Delgado, F Smith, E Mclaughlin, N Tuholski, H Senn, D Lei, A Castano-Almendral, J Carmo-Pereira, Oliveira Costa, F Henriques, E, H Harvey, A Lipton, M Simmonds, A Calvert, D Newell, L Gumbrell, C: Turbow, M, Kaye

BMJ

October 12, 1991

10.1136/bmj.303.6807.884

Cited by 306Open Access

Full Text

Abstract

OBJECTIVES: To consider the role of platinum and the relative merits of single agent and combination chemotherapy in the treatment of advanced ovarian cancer. DESIGN: Formal quantitative overview using updated individual patient data from all available randomised trials (published and unpublished). SUBJECTS: 8139 patients (6408 deaths) included in 45 different trials. RESULTS: No firm conclusions could be reached. Nevertheless, the results suggest that in terms of survival immediate platinum based treatment was better than non-platinum regimens (overall relative risk 0.93; 95% confidence interval 0.83 to 1.05); platinum in combination was better than single agent platinum when used in the same dose (overall relative risk 0.85; 0.72 to 1.00); and cisplatin and carboplatin were equally effective (overall relative risk 1.05; 0.94 to 1.18). CONCLUSIONS: In the past, randomised clinical trials of chemotherapy in advanced ovarian cancer have been much too small to detect the degree of benefit which this overview suggests is realistic for currently available chemotherapeutic regimens. Hence a new trial comparing cisplatin, doxorubicin, and cyclophosphamide (CAP) with carboplatin has been launched and plans to accrue 2000 patients.

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