Multiple early factors anticipate post-acute COVID-19 sequelae
Yapeng Su(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), Dan Yuan(University of Washington), Daniel Chen(University of Washington), Raymond T. Ng(University of Washington), Kai Wang(Institute for Systems Biology), Jongchan Choi(Institute for Systems Biology), Sarah Li(Institute for Systems Biology), Sunga Hong(Institute for Systems Biology), Rongyu Zhang(University of Washington), Jingyi Xie(University of Washington), Sergey A. Kornilov(Institute for Systems Biology), Kelsey Scherler(Institute for Systems Biology), Ana Jimena Pavlovitch-Bedzyk(Stanford University), Shen Dong(University of California, San Francisco), Christopher Lausted(Institute for Systems Biology), Inyoul Lee(Institute for Systems Biology), Shannon Fallen(Institute for Systems Biology), Chengzhen L. Dai(Institute for Systems Biology), Priyanka Baloni(Institute for Systems Biology), Brett Smith(Institute for Systems Biology), Venkata R. Duvvuri(Institute for Systems Biology), Kristin G. Anderson(University of Washington), Jing Li(Stanford University), Fan Yang(Stanford University), Caroline J. Duncombe(University of Washington), Denise J. McCulloch(University of Washington), Clifford Rostomily(Institute for Systems Biology), Pamela Troisch(Institute for Systems Biology), Jing Zhou(IsoPlexis (United States)), Sean Mackay(IsoPlexis (United States)), Quinn DeGottardi(Adaptive Biotechnologies (United States)), Damon May(Adaptive Biotechnologies (United States)), Ruth Taniguchi(Adaptive Biotechnologies (United States)), Rachel Gittelman(Adaptive Biotechnologies (United States)), Mark Klinger(Adaptive Biotechnologies (United States)), Thomas M. Snyder(Adaptive Biotechnologies (United States)), Ryan Roper(Institute for Systems Biology), Gladys Wojciechowska(Medical University of Białystok), Kim M. Murray(Institute for Systems Biology), Rick Edmark(Institute for Systems Biology), Simon Evans(Institute for Systems Biology), Lesley Jones(Institute for Systems Biology), Yong Zhou(Institute for Systems Biology), Lee Rowen(Institute for Systems Biology), Rachel Liu(Institute for Systems Biology), William Chour(Institute for Systems Biology), Heather A. Algren(Providence College), William R. Berrington(Providence College), Julie A. Wallick(Providence College), Rebecca A. Cochran(Providence College), Mary Micikas(Providence College), Terri Wrin, Christos J. Petropoulos, Hunter Cole(Saint John's Health Center), Trevan Fischer(Saint John's Health Center), Wei Wei(Institute for Systems Biology), Dave S.�B. Hoon(Saint John's Health Center), Nathan D. Price(Institute for Systems Biology), Naeha Subramanian(University of Washington), Joshua A. Hill(Infectious Disease Research Institute), Jennifer Hadlock(Institute for Systems Biology), Andrew T. Magis(Institute for Systems Biology), Antoni Ribas(University of California, Los Angeles), Lewis L. Lanier(University of California, San Francisco), Scott D. Boyd(Stanford University), Jeffrey A. Bluestone(University of California, San Francisco), Helen Y. Chu(University of Washington), Leroy Hood(Providence College), Raphaël Gottardo(University of Washington), Philip D. Greenberg(University of Washington), Mark M. Davis(Howard Hughes Medical Institute), Jason D. Goldman(Providence College), James R. Heath(University of Washington)
Cited by 1,181Open Access
Abstract
T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies.
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