Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection <i>In Vitro</i> , despite Eliciting a Prolonged Antiviral Response
Akshamal M. Gamage(Duke-NUS Medical School), Kai Sen Tan(National University of Singapore), Wharton O. Y. Chan(Duke-NUS Medical School), Zhe Zhang Ryan Lew(National University of Singapore), Jing Liu(National University of Singapore), Chee Wah Tan(Duke-NUS Medical School), Deepa Rajagopalan(Genome Institute of Singapore), Quy Xiao Xuan Lin(Genome Institute of Singapore), Le Min Tan(Genome Institute of Singapore), Prasanna Nori Venkatesh(Genome Institute of Singapore), Yew Kwang Ong(National University of Singapore), Mark Thong(National University of Singapore), Raymond Tzer Pin Lin(National University of Singapore), Shyam Prabhakar(Genome Institute of Singapore), De Yun Wang(National University of Singapore), Lin‐Fa Wang(SingHealth Duke-NUS Academic Medical Centre)
Cited by 32Open Access
Abstract
differentiated human NECs are persistently infected with SARS-CoV-2 for up to 28 dpi. This viral replication occurred despite the presence of an antiviral gene signature across all NEC cell types even at 28 dpi. This indicates that epithelial cell intrinsic antiviral responses are insufficient for the clearance of SARS-CoV-2, implying an essential role for tissue-resident and infiltrating immune cells for eventual viral clearance from infected airway tissue in COVID-19 patients.
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