PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours

Hongfeng Yuan; Man Zhao; Lina Zhao; Haolin Yun; Guang Yang; Yu Geng; Yufei Wang; Wei Zheng; Ying Yuan; Tianqiang Song; Junqi Niu; Xiaodong Zhang

doi:10.1038/s41401-021-00841-y

PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours

Hongfeng Yuan(Tianjin Medical University Cancer Institute and Hospital), Man Zhao(Tianjin Medical University Cancer Institute and Hospital), Lina Zhao(Nankai University), Haolin Yun(Nankai University), Guang Yang(Tianjin Medical University Cancer Institute and Hospital), Yu Geng(Nankai University), Yufei Wang(Nankai University), Wei Zheng(Nankai University), Ying Yuan(Nankai University), Tianqiang Song(Tianjin Medical University Cancer Institute and Hospital), Junqi Niu(First Hospital of Jilin University), Xiaodong Zhang(Tianjin Medical University Cancer Institute and Hospital)

Acta Pharmacologica Sinica

January 19, 2022

10.1038/s41401-021-00841-y

Cited by 57Open Access

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