Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery

Wei Chen(Massachusetts Institute of Technology), Jacob Wainer(Massachusetts Institute of Technology), Si Won Ryoo(Massachusetts Institute of Technology), Xiaoyue Qi(Massachusetts Institute of Technology), Rong Chang(Massachusetts Institute of Technology), Jason Li(Massachusetts Institute of Technology), Seung Ho Lee(Massachusetts Institute of Technology), Seokkee Min(Massachusetts Institute of Technology), Adam Wentworth(Brigham and Women's Hospital), Joy Collins(Brigham and Women's Hospital), Siddartha Tamang(Massachusetts Institute of Technology), Keiko Ishida(Brigham and Women's Hospital), Alison Hayward(Massachusetts Institute of Technology), Róbert Langer(Massachusetts Institute of Technology), Giovanni Traverso(Brigham and Women's Hospital)
Science Advances
January 5, 2022
10.1126/sciadv.abk1792
Cited by 126Open Access
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Abstract

-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract.

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