Transcriptional Differences in Luminal Epithelial Cells in Patients with and without Lymph Node Involvement in TNBC

Abstract

TNBC is an aggressive subtype of breast case which is hard to treat due to the high degree of heterogeneity and higher frequency of metastasis. Luminal progenitor cells (LPs) were previously suggested to play a role in the metastasis in TNBC. In this study, we use a publicly available scRNA-Seq dataset (GSE118389) to address the differences in transcriptional signatures of LPs and luminal epithelial cells in TNBC patients with and without lymph node involvement. When comparing the expression level of genes, we found there is a obvious difference in luminal epithelial cells between TNBC patients with and without lymph node involvement.