An ionizable lipid toolbox for RNA delivery
Xuexiang Han(University of Pennsylvania), Hanwen Zhang(University of Pennsylvania), Kamila Butowska(University of Gdańsk), Kelsey L. Swingle(University of Pennsylvania), Mohamad‐Gabriel Alameh(University of Pennsylvania), Drew Weissman(University of Pennsylvania), Michael J. Mitchell(University of Pennsylvania)
Cited by 573Open Access
Abstract
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
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