AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
David Goertsen(California Institute of Technology), Viviana Gradinaru(California Institute of Technology)
Cited by 414
Related Papers
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
|Nature Neuroscience|2020|396
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
|Science Advances|2023|67
Widespread and targeted gene expression by systemic AAV vectors: Production, purification, and administration
|bioRxiv (Cold Spring Harbor Laboratory)|2018|17
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
|bioRxiv (Cold Spring Harbor Laboratory)|2023|6
AAVs targeting human carbonic anhydrase IV enhance gene delivery to the brain
|Cell Reports|2025|6