HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses

Pavlo A. Nesterenko(University of California, Los Angeles), Jami McLaughlin(University of California, Los Angeles), Brandon L. Tsai(University of California, Los Angeles), Giselle Burton Sojo(University of California, Los Angeles), Donghui Cheng(Broad Center), Daniel Zhao(Broad Center), Zhiyuan Mao(University of California, Los Angeles), Nathanael J. Bangayan(University of California, Los Angeles), Matthew B. Obusan(University of California, Los Angeles), Yapeng Su(Institute for Systems Biology), Raymond T. Ng(Institute for Systems Biology), William Chour(California Institute of Technology), Jingyi Xie(Institute for Systems Biology), Yan-Ruide Li(University of California, Los Angeles), Derek Lee(University of California, Los Angeles), Miyako Noguchi(University of California, Los Angeles), Camille Carmona(University of California, Los Angeles), John W. Phillips(University of California, Los Angeles), Jocelyn T. Kim(University of California, Los Angeles), Lili Yang(University of California, Los Angeles), James R. Heath(University of California, Los Angeles), Paul C. Boutros(Broad Center), Owen N. Witte(University of California, Los Angeles)
Cell Reports
December 1, 2021
10.1016/j.celrep.2021.110167
Cited by 36Open Access
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Abstract

T cells can recognize evolutionarily diverse coronaviruses. Analysis of individual TCR clones may help define vaccine epitopes that can induce long-term immunity against SARS-CoV-2 and other coronaviruses.

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