Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria
Xianliang Zhao(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Zhuang‐Gui Chen(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Tian‐Ci Yang(Zhongshan Hospital of Xiamen University), Ming Jiang(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Jie Wang(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Zhi-xue Cheng(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Manjun Yang(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Jiaxin Zhu(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Tiantuo Zhang(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Hui Li(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Bo Peng(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)), Xuan‐xian Peng(Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou))
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Abstract
elevated antibiotic resistance in antibiotic-sensitive strains. In addition, glutamine retarded the development of ampicillin resistance. These results may facilitate future development of effective approaches for preventing or managing chronic, multidrug-resistant bacterial infections, bacterial persistence, and difficult-to-treat bacterial biofilms.
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