Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

Jiansong Fang; Pengyue Zhang; Yadi Zhou; Chien‐Wei Chiang; Juan Tan; Yuan Hou; Shaun R. Stauffer; Lang Li; Andrew A. Pieper; Jeffrey L. Cummings; Feixiong Cheng

doi:10.1038/s43587-021-00138-z

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

Jiansong Fang(Cleveland Clinic Lerner College of Medicine), Pengyue Zhang(Indiana University – Purdue University Indianapolis), Yadi Zhou(Cleveland Clinic Lerner College of Medicine), Chien‐Wei Chiang(The Ohio State University), Juan Tan(Cleveland Clinic Lerner College of Medicine), Yuan Hou(Cleveland Clinic Lerner College of Medicine), Shaun R. Stauffer(Cleveland Clinic Lerner College of Medicine), Lang Li(The Ohio State University), Andrew A. Pieper(University Hospitals Cleveland Medical Center), Jeffrey L. Cummings(University of Nevada, Las Vegas), Feixiong Cheng(Cleveland Clinic Lerner College of Medicine)

Nature Aging

December 6, 2021

10.1038/s43587-021-00138-z

Cited by 198Open Access

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