A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B.

E. Britta-Mareen Traenckner(University of Freiburg), S. Wilk(University of Freiburg), Patrick A. Baeuerle(University of Freiburg)
The EMBO Journal
November 1, 1994
10.1002/j.1460-2075.1994.tb06878.x
Cited by 716Open Access
Full Text

Abstract

Related Papers

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
Ralf Schreck, P. Rieber, Patrick A. Baeuerle|The EMBO Journal|1991|3.8k
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
Patrick A. Baeuerle, D Baltimore|Cell|1988|1.2k
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
Klaus Schulze‐Osthoff, Annette Bakker, Bart Vanhaesebroeck et al.|Journal of Biological Chemistry|1992|940
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
Yasuko Murakami, Senya Matsufuji, Takaaki Kameji et al.|Nature|1992|785
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene‐inductive effects of TNF.
Klaus Schulze‐Osthoff, Rudi Beyaert, Veronique Vandevoorde et al.|The EMBO Journal|1993|579