Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)

Ester Álvarez‐Benedicto(The University of Texas Southwestern Medical Center), Lukas Farbiak(The University of Texas Southwestern Medical Center), Martha Márquez Ramírez(The University of Texas Southwestern Medical Center), Xu Wang(The University of Texas Southwestern Medical Center), Lindsay T. Johnson(The University of Texas Southwestern Medical Center), Osamah Mian(The University of Texas Southwestern Medical Center), Erick Guerrero(The University of Texas Southwestern Medical Center), Daniel J. Siegwart(The University of Texas Southwestern Medical Center)
Biomaterials Science
November 30, 2021
10.1039/d1bm01454d
Cited by 207Open Access
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Abstract

. These findings were then applied to Selective Organ Targeting (SORT) LNPs to manipulate and control spleen-specific delivery. Overall, selection of the phospholipid in LNPs provides an important handle to design and optimize LNPs for improved mRNA delivery and more effective therapeutics.

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