Microglia contribute to the propagation of Aβ into unaffected brain tissue
Paolo d’Errico(University of Freiburg), Stephanie Ziegler‐Waldkirch(University of Freiburg), Vanessa Aires(University of Freiburg), Philippe Hoffmann(University of Freiburg), Charlotte Mezö(University of Freiburg), Daniel Erny(University of Freiburg), Laura Sebastián Monasor(German Center for Neurodegenerative Diseases), Sabine Liebscher(Munich Cluster for Systems Neurology), Vidhya M. Ravi(University of Freiburg), Kevin Joseph(University of Freiburg), Oliver Schnell(University of Freiburg), Katrin Kierdorf(University of Freiburg), Ori Staszewski(University of Freiburg), Sabina Tahirović(German Center for Neurodegenerative Diseases), Marco Prinz(University of Freiburg), Melanie Meyer‐Luehmann(University of Freiburg)
Cited by 208Open Access
Abstract
Abstract Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.
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