A Facile Low-Dose Photosensitizer-Incorporated Dissolving Microneedles-Based Composite System for Eliciting Antitumor Immunity and the Abscopal Effect
Qiong Bian(Zhejiang University), Lingling Huang(Second Affiliated Hospital of Zhejiang University), Yihua Xu(Zhejiang University), Ruxuan Wang(Zhejiang University), Yueting Gu(Zhejiang University), Anran Yuan(Second Affiliated Hospital of Zhejiang University), Xiaolu Ma(Zhejiang University), Jingyi Hu(Zhejiang University), Yuefeng Rao(Zhejiang University), Donghang Xu(Second Affiliated Hospital of Zhejiang University), Hangxiang Wang(Zhejiang University), Jianqing Gao(Zhejiang University)
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Abstract
through reactive oxygen species (ROS) generation. More importantly, a significant abscopal effect was also elicited by activating immunogenic cell death (ICD) and releasing danger-associated molecular patterns (DAMPs), which in turn promoted dendritic cells (DCs) maturation and the subsequent antigen presentation, thereby facilitating the T-cell-mediated immune response without synergetic immunotherapies. Collectively, our findings indicate the facile, controllable, and fast-dissolving microneedles patch with a low dose of photosensitizers presented great therapeutic potential for enhanced photoimmunotherapy.
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