DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia(University of Padua), Bálint Mészáros(European Molecular Biology Laboratory), Edoardo Salladini(University of Padua), András Hatos(University of Padua), Rita Pancsa(Institute of Molecular Life Sciences), Lucía B. Chemes(Consejo Nacional de Investigaciones Científicas y Técnicas), Mátyás Pajkos(Eötvös Loránd University), Tamás Lázár(Vrije Universiteit Brussel), Samuel Peña‐Díaz(Universitat Autònoma de Barcelona), Jaime Santos(Universitat Autònoma de Barcelona), Veronika Ács(Institute of Molecular Life Sciences), Nazanin Farahi(Vrije Universiteit Brussel), Erzsébet Fichó(Institute of Molecular Life Sciences), Maria Cristina Aspromonte(University of Padua), Claudio Bassot(Stockholm University), Anastasia Chasapi(Centre for Research and Technology Hellas), Norman E. Davey(Institute of Cancer Research), Radoslav Davidović(University of Belgrade), László Dobson(Institute of Molecular Life Sciences), Arne Elofsson(Stockholm University), Gábor Erdős(Eötvös Loránd University), Pascale Gaudet(SIB Swiss Institute of Bioinformatics), Michelle Giglio(University of Maryland, Baltimore), Juliana Glavina(Consejo Nacional de Investigaciones Científicas y Técnicas), Javier Iserte(Fundación Instituto Leloir), Valentín Iglesias(Universitat Autònoma de Barcelona), Zsófia E. Kálmán(Pázmány Péter Catholic University), Matteo Lambrughi(Danish Cancer Society), Emanuela Leonardi(University of Padua), Sonia Longhi(Centre National de la Recherche Scientifique), Sandra Macedo‐Ribeiro(Universidade do Porto), Emiliano Maiani(Danish Cancer Society), Julia Marchetti(National University of Quilmes), Cristina Marino‐Buslje(Fundación Instituto Leloir), Attila Mészáros(Vrije Universiteit Brussel), Alexander Miguel Monzón(University of Padua), Giovanni Minervini(University of Padua), Suvarna Nadendla(University of Maryland, Baltimore), Juliet F. Nilsson(Centre National de la Recherche Scientifique), Marián Novotný(Výzkumná Stanice Vinohradnická), Christos Ouzounis(Centre for Research and Technology Hellas), Nicolás Palópoli(National University of Quilmes), Elena Papaleo(Danish Cancer Society), Pedro José Barbosa Pereira(Universidade do Porto), Gabriele Pozzati(Stockholm University), Vasilis J. Promponas(University of Cyprus), Jordi Pujols(Universitat Autònoma de Barcelona), Alma Carolina Sánchez-Rocha(Charles University), Martin Salas(National University of Quilmes), Luciana Rodriguez Sawicki(National University of Quilmes), Éva Schád(Institute of Molecular Life Sciences), Aditi Shenoy(Stockholm University), Tamás Szaniszló(Eötvös Loránd University), Konstantinos D. Tsirigos(European Bioinformatics Institute), Nevena Veljković(University of Belgrade), Gustavo Parisi(National University of Quilmes), Salvador Ventura(Institució Catalana de Recerca i Estudis Avançats), Zsuzsanna Dosztányi(Eötvös Loránd University), Péter Tompa(Vrije Universiteit Brussel), Silvio C. E. Tosatto(University of Padua), Damiano Piovesan(University of Padua)
Nucleic Acids Research
October 20, 2021
10.1093/nar/gkab1082
Cited by 188Open Access
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Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

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