The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
Jack McCowan(MRC Centre for Regenerative Medicine), Frédéric Fercoq(Cancer Research UK), Phoebe M. Kirkwood(MRC Centre for Regenerative Medicine), Wouter T’Jonck(MRC Centre for Regenerative Medicine), Lizi M. Hegarty(MRC Centre for Regenerative Medicine), Connar M. Mawer(Centre for Inflammation Research), Richard Cunningham(MRC Centre for Regenerative Medicine), Ananda S. Mirchandani(MRC Centre for Regenerative Medicine), Anna M. Hoy(Centre for Inflammation Research), Duncan C. Humphries(MRC Centre for Regenerative Medicine), Gareth‐Rhys Jones(MRC Centre for Regenerative Medicine), Carsten Gram Hansen(MRC Centre for Regenerative Medicine), Nik Hirani(MRC Centre for Regenerative Medicine), Stephen J. Jenkins(MRC Centre for Regenerative Medicine), Sandrine Henri(Centre National de la Recherche Scientifique), Bernard MALISSEN(Centre National de la Recherche Scientifique), Sarah R. Walmsley(MRC Centre for Regenerative Medicine), David H. Dockrell(MRC Centre for Regenerative Medicine), Philippa T. K. Saunders(MRC Centre for Regenerative Medicine), Leo M. Carlin(Cancer Research UK), Calum C. Bain(MRC Centre for Regenerative Medicine)
Cited by 65Open Access
Abstract
. Last, we show that EGR2 is required for repopulation of the alveolar niche after sterile, bleomycin-induced lung injury and demonstrate that EGR2-dependent, monocyte-derived alveolar macrophages are vital for effective tissue repair after injury. Collectively, we demonstrate that EGR2 is an indispensable component of the transcriptional network controlling the identity and function of alveolar macrophages in health and disease.
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