Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries
Chao Yan(Xuzhou Medical College), Qian-Yang Zhou(Xuzhou Medical College), Jing Wu(Xuzhou Medical College), Na Xu(Xuzhou Medical College), Ying Du(Xuzhou Medical College), Jing Li(Xuzhou Medical College), Jixin Liu(Xuzhou Medical College), Stephane Koda(Xuzhou Medical College), Beibei Zhang(Xuzhou Medical College), Qian Yu(Xuzhou Medical College), Huimin Yang(Xuzhou Medical College), Xiangyang Li(Xuzhou Medical College), Bo Zhang(Xuzhou Medical College), Yinhai Xu(Xuzhou Medical College), Jiaxu Chen(National Institute for Parasitic Diseases), Zhongdao Wu(Sun Yat-sen University), Xing‐Quan Zhu(Shanxi Agricultural University), Renxian Tang(Xuzhou Medical College), Kuiyang Zheng(Xuzhou Medical College)
Cited by 69Open Access
Abstract
Significance Infection with liver flukes (such as Clonorchis sinensi s) can induce severe biliary injuries. But we don’t know how it happens. Here, we find that a microRNA Csi-let-7a-5p delivered by extracellular vesicles from C. sinensis is prone to M1-like activation of macrophages, thus leading to biliary proinflammatory responses and biliary injuries. These findings indicate a molecular mechanism contributing to biliary injuries caused by C. sinensis .
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