The IntAct database: efficient access to fine-grained molecular interaction data

Noemí del‐Toro(European Bioinformatics Institute), Anjali Shrivastava(European Bioinformatics Institute), Eliot Ragueneau(European Bioinformatics Institute), Birgit Meldal(European Bioinformatics Institute), Colin Combe(Wellcome Centre for Cell Biology), Elisabet Barrera(European Bioinformatics Institute), Livia Perfetto(European Bioinformatics Institute), Karyn How(University of California, Los Angeles), Prashansa Ratan(University of California, Los Angeles), Gautam Shirodkar(University of California, Los Angeles), Odilia Lu(University of California, Los Angeles), Bálint Mészáros(European Molecular Biology Laboratory), Xavier Watkins(European Bioinformatics Institute), Sangya Pundir(European Bioinformatics Institute), Luana Licata(University of Rome Tor Vergata), Marta Iannuccelli(University of Rome Tor Vergata), Matteo Pellegrini(University of California, Los Angeles), María Martin(European Bioinformatics Institute), Simona Panni(University of Calabria), Margaret Duesbury(European Bioinformatics Institute), Sylvain D. Vallet(Université Claude Bernard Lyon 1), Juri Rappsilber(Wellcome Centre for Cell Biology), Sylvie Ricard‐Blum(Université Claude Bernard Lyon 1), Gianni Cesareni(University of Rome Tor Vergata), Łukasz Salwiński(University of California, Los Angeles), Sandra Orchard(European Bioinformatics Institute), Pablo Porras(European Bioinformatics Institute), Kalpana Panneerselvam(European Bioinformatics Institute), Henning Hermjakob(European Bioinformatics Institute)
Nucleic Acids Research
October 21, 2021
10.1093/nar/gkab1006
Cited by 379Open Access
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Abstract

The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.

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