Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
W. Zac Stephens(University of Utah), Jason L. Kubinak(University of South Carolina), Arevik Ghazaryan(University of Utah), Kaylyn M. Bauer(University of Utah), Rickesha Bell(University of Utah), Kate Buhrke(University of Utah), Tyson R. Chiaro(University of Utah), Allison M. Weis(University of Utah), William W. Tang(University of Utah), Josh K. Monts(University of Utah), Ray Soto(University of Utah), H. Atakan Ekiz(Izmir Institute of Technology), Ryan M. O’Connell(University of Utah), June L. Round(University of Utah)
Cited by 36Open Access
Abstract
) are healthy but have fewer microbial-bound IgA, regulatory T cells (Tregs), and immune repertoire selection. This was associated with increased interindividual microbiota variation and altered proportions of two taxa in the ileum where MHC class II on IECs is highest. Intestinal mononuclear phagocytes (MNPs) have similar MHC class II transcription but less surface MHC class II and are capable of acquiring MHC class II from IECs. Thus, epithelial-myeloid interactions mediate development of adaptive responses to microbial antigens within the gastrointestinal tract.
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