Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Melissa B. Pappalardi(GlaxoSmithKline (United States)), Rab K. Prinjha(GlaxoSmithKline (United States)), Jacques Briand(GlaxoSmithKline (United States)), Dean E. McNulty, David T. Fosbenner(GlaxoSmithKline (United States)), Arthur Groy(GlaxoSmithKline (United States)), Charles F. McHugh(GlaxoSmithKline (United States)), Ashley K. Wiseman(Van Andel Institute), Kristen Wong(GlaxoSmithKline (United States)), Paola Grandi(GlaxoSmithKline (Germany)), Cunyu Zhang(GlaxoSmithKline (United States)), Aidan G. Gilmartin(GlaxoSmithKline (United States)), Sarath Pathuri(The University of Texas MD Anderson Cancer Center), Amy Taylor(GlaxoSmithKline (United States)), Elisabeth A. Minthorn(GlaxoSmithKline (United States)), Anthony J. Jurewicz(GlaxoSmithKline (United States)), Alan P. Graves(GlaxoSmithKline (United States)), Morris Muliaditan(Advanced Pharma), Shawn W. Foley(GlaxoSmithKline (United States)), Susan Merrihew(GlaxoSmithKline (United States)), Thilo Werner(GlaxoSmithKline (Germany)), Nino Campobasso(GlaxoSmithKline (United States)), Mehul Patel(GlaxoSmithKline (United States)), Makda Mebrahtu(GlaxoSmithKline (United States)), H. Christian Eberl(GlaxoSmithKline (Germany)), Mark Cockerill(University of Manchester), Michael Steidel(GlaxoSmithKline (Germany)), Anna Rutkowska(GlaxoSmithKline (Germany)), Alexandra Stowell(University of Manchester), Stuart P. Romeril(GlaxoSmithKline (United States)), Marcus Bantscheff, Thau Ho(GlaxoSmithKline (United States)), Kathryn Keenan(GlaxoSmithKline (United States)), Christian Sherk(GlaxoSmithKline (United States)), Emma Fairweather(University of Manchester), Lourdes Rueda(GlaxoSmithKline (United States)), Charlotte Burt(University of Manchester), Christopher S. Kershaw(University of Manchester), Jessica L. Handler(GlaxoSmithKline (United States)), Kristin Goldberg(University of Manchester), Andrew B. Benowitz(GlaxoSmithKline (United States)), Wendy A. Kellner(GlaxoSmithKline (United States)), Mei Li(Soochow University), Roger J. Butlin(University of Manchester), Ali Raoof(University of Manchester), P Chapman(University of Manchester), Helai P. Mohammad(GlaxoSmithKline (United States)), Jon‐Paul Jaworski(GlaxoSmithKline (United States)), Xing Zhang(Emory University), J.R. Horton(The University of Texas MD Anderson Cancer Center)
Nature Cancer
September 27, 2021
Cited by 279


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