Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chih-Yuan Chuang(Cytokinetics (United States)), Scott E. Collibee(Cytokinetics (United States)), Luke Ashcraft(Cytokinetics (United States)), Wenyue Wang(Cytokinetics (United States)), Mark Vander Wal(Cytokinetics (United States)), Xiaolin Wang(Cytokinetics (United States)), Darren T. Hwee(Cytokinetics (United States)), Yangsong Wu(Cytokinetics (United States)), Jingying Wang(Cytokinetics (United States)), Eva R. Chin(Cytokinetics (United States)), Peadar Cremin(Cytokinetics (United States)), Jeanelle Zamora(Cytokinetics (United States)), James J. Hartman(Cytokinetics (United States)), Julia Schaletzky(Cytokinetics (United States)), Eddie Wehri(Cytokinetics (United States)), Laura Robertson(Cytokinetics (United States)), Fady I. Malik(Cytokinetics (United States)), B. Paul Morgan(Cytokinetics (United States))
Cited by 167Open Access
Abstract
similar to predictions and was able to reach steady state concentration within the desired two-week window.
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