The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication
Benjamin E. Nilsson-Payant(Icahn School of Medicine at Mount Sinai), Skyler Uhl(Icahn School of Medicine at Mount Sinai), Adrien Grimont(Cornell University), Ashley S. Doane(Cornell University), Phillip Cohen(Icahn School of Medicine at Mount Sinai), Roosheel S. Patel(Icahn School of Medicine at Mount Sinai), Christina A. Higgins(Icahn School of Medicine at Mount Sinai), Joshua A. Acklin(Icahn School of Medicine at Mount Sinai), Yaron Bram(Cornell University), Vasuretha Chandar(Cornell University), Daniel Blanco-Melo(Icahn School of Medicine at Mount Sinai), Maryline Panis(Icahn School of Medicine at Mount Sinai), Jean K. Lim(Icahn School of Medicine at Mount Sinai), Olivier Elemento(Cornell University), Robert E. Schwartz(Cornell University), Brad R. Rosenberg(Icahn School of Medicine at Mount Sinai), Rohit Chandwani(Cornell University), Benjamin R. tenOever(Icahn School of Medicine at Mount Sinai)
Cited by 107Open Access
Abstract
The COVID-19 pandemic has caused significant mortality and morbidity around the world. Although effective vaccines have been developed, large parts of the world remain unvaccinated while new SARS-CoV-2 variants keep emerging. Furthermore, despite extensive efforts and large-scale drug screenings, no fully effective antiviral treatment options have been discovered yet. Therefore, it is of the utmost importance to gain a better understanding of essential factors driving SARS-CoV-2 replication to be able to develop novel approaches to target SARS-CoV-2 biology.
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