Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys

Sheng Zhao(Wuhan University), Wei Li(Wuhan University), Weimin Yu(Wuhan University), Ting Rao(Wuhan University), Haoyong Li(Wuhan University), Yuan Ruan(Wuhan University), Run Yuan(Wuhan University), Chenglong Li(Wuhan University), Jinzhuo Ning(Wuhan University), Siqi Li(Wuhan University), Chen Wu(Wuhan University), Cheng Fan(Wuhan University), Xiangjun Zhou(Wuhan University)
Theranostics
January 1, 2021
10.7150/thno.62820
Cited by 169Open Access
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Abstract

Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.

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