Endothelial cell membrane-based biosurface for targeted delivery to acute injury: analysis of leukocyte-mediated nanoparticle transportation

Fang Wang(Fujian Medical University), Wenda Hou(Peking University), Chenglu Xiao(Peking University), Yaoyao Hao(Peking University), Ni Su(Peking University), Yu Deng(Fujian Medical University), Jieting Wang(Fujian Medical University), Luying Yu(Fujian Medical University), Jing-Ming Xie(Peking University), Jing‐Wei Xiong(Peking University), Ying Luo(Tufts University)
Nanoscale
January 1, 2021
Cited by 9

Abstract

the motility of neutrophils. Utilizing the transgenic zebrafish model, the leukocyte-mediated transportation and biodistribution of EM-Ps were further visualized in real time at the whole-organism level. Endothelial membranes provided a new biosurface for developing biomimetic vehicles to allow the immune cell-mediated transportation and may enable advanced systems for active and highly efficient drug delivery.


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