A resource of high-quality and versatile nanobodies for drug delivery

Zhuolun Shen; Yufei Xiang; Sandra Vergara; Apeng Chen; Zhengyun Xiao; Ulises Santiago; Changzhong Jin; Zhe Sang; Jiadi Luo; Kong Chen; Dina Schneidman‐Duhovny; Carlos J. Camacho; Guillermo Calero; Baoli Hu; Yi Shi

doi:10.1016/j.isci.2021.103014

A resource of high-quality and versatile nanobodies for drug delivery

Zhuolun Shen(University of Pittsburgh), Yufei Xiang(University of Pittsburgh), Sandra Vergara(University of Pittsburgh), Apeng Chen(University of Pittsburgh), Zhengyun Xiao(University of Pittsburgh), Ulises Santiago(University of Pittsburgh), Changzhong Jin(University of Pittsburgh), Zhe Sang(University of Pittsburgh), Jiadi Luo(University of Pittsburgh), Kong Chen(University of Pittsburgh), Dina Schneidman‐Duhovny, Carlos J. Camacho(University of Pittsburgh), Guillermo Calero(University of Pittsburgh), Baoli Hu(University of Pittsburgh), Yi Shi(University of Pittsburgh)

iScience

August 21, 2021

10.1016/j.isci.2021.103014

Cited by 39Open Access

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Abstract

-cytokine fusion constructs "Duraleukin" and demonstrated Duraleukin's high preclinical efficacy for cancer treatment in a melanoma model. This high-quality and versatile Nb toolkit will help tailor drug half-life to specific medical needs.

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