The origins of SARS-CoV-2: A critical review
Edward C. Holmes(The University of Sydney), Stephen A. Goldstein(University of Utah), Angela L. Rasmussen(University of Saskatchewan), David L. Robertson(MRC University of Glasgow Centre for Virus Research), Alexander Crits‐Christoph(University of California, Berkeley), Joel O. Wertheim(University of California San Diego), Simon J. Anthony(University of California, Davis), William Barclay(Imperial College London), Maciej F. Boni(Pennsylvania State University), Peter C. Doherty(The University of Melbourne), Jeremy Farrar(Wellcome Trust), Jemma L. Geoghegan(New Zealand Institute for Public Health and Forensic Science), Xiaowei Jiang(Xi’an Jiaotong-Liverpool University), Julian L. Leibowitz(Texas A&M University), Stuart J. D. Neil(Guy's Hospital), Tim Skern(Max Perutz Labs), Susan R. Weiss(University of Pennsylvania), Michael Worobey(University of Arizona), Kristian G. Andersen(Scripps Research Institute), Robert F. Garry(Tulane University), Andrew Rambaut(Institut de Biologia Evolutiva)
Cited by 509Open Access
Abstract
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.
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