Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Jesper Bäckdahl; Lovisa Franzén; Lucas Massier; Qian Li; Jutta Jalkanen; Hui Gao; Alma Andersson; Nayanika Bhalla; Anders Thorell; Mikael Rydén; Patrik L. Ståhl; Niklas Mejhert

doi:10.1016/j.cmet.2021.07.018

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Jesper Bäckdahl(Karolinska University Hospital), Lovisa Franzén(Science for Life Laboratory), Lucas Massier(Karolinska University Hospital), Qian Li(Karolinska University Hospital), Jutta Jalkanen(Karolinska University Hospital), Hui Gao(Karolinska Institutet), Alma Andersson(Science for Life Laboratory), Nayanika Bhalla(Science for Life Laboratory), Anders Thorell(Karolinska Institutet), Mikael Rydén(Karolinska University Hospital), Patrik L. Ståhl(Science for Life Laboratory), Niklas Mejhert(Karolinska University Hospital)

Cell Metabolism

August 10, 2021

10.1016/j.cmet.2021.07.018

Cited by 214Open Access

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Abstract

displayed a transcriptional response to insulin. Altogether, by mining this multimodal resource we identify that human WAT is composed of three classes of mature adipocytes, only one of which is insulin responsive.

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