Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Yao‐Xin Lin; Yi Wang; Jianxun Ding; Aiping Jiang; Jie Wang; Mian Yu; Sara Blake; Shuaishuai Liu; Charles J. Bieberich; Omid C. Farokhzad; Lin Mei; Hao Wang; Jinjun Shi

doi:10.1126/scitranslmed.aba9772

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Yao‐Xin Lin(Brigham and Women's Hospital), Yi Wang(Brigham and Women's Hospital), Jianxun Ding(Brigham and Women's Hospital), Aiping Jiang(Boston Children's Hospital), Jie Wang(National Center for Nanoscience and Technology), Mian Yu(Sun Yat-sen University), Sara Blake(Tufts University), Shuaishuai Liu(University of Maryland, Baltimore County), Charles J. Bieberich(University of Maryland, Baltimore), Omid C. Farokhzad(Brigham and Women's Hospital), Lin Mei(Sun Yat-sen University), Hao Wang(National Center for Nanoscience and Technology), Jinjun Shi(Brigham and Women's Hospital)

Science Translational Medicine

June 23, 2021

10.1126/scitranslmed.aba9772

Cited by 242Open Access

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Abstract

The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.

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