Undisclosed, unmet and neglected challenges in multi-omics studies

Abstract

Multi-omics approaches have become a reality in both large genomics projects and small laboratories. However, the multi-omics research community still faces a number of issues that have either not been sufficiently discussed or for which current solutions are still limited. In this Perspective, we elaborate on these limitations and suggest points of attention for future research. We finally discuss new opportunities and challenges brought to the field by the rapid development of single-cell high-throughput molecular technologies. Multi-omics studies have been increasingly used to better understand biological samples and infer molecular interactions. Nevertheless, a number of challenges must still be addressed to take full advantage of multi-omics data and to avoid reaching potentially incorrect conclusions.