The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers

Éva Compérat(Vienna General Hospital), Mahul B. Amin(University of Southern California), Jonathan I. Epstein(Johns Hopkins University), Donna E. Hansel(Oregon Health & Science University), Gladell P. Paner(University of Chicago), Hikmat Al‐Ahmadie, Larry True(University of Washington), Dilek Bayder(Koç University), Trinity J. Bivalacqua(Johns Hopkins University), Fadi Brimo(Université de Montréal), Liang Cheng(Indiana University School of Medicine), John C. Cheville(Mayo Clinic in Arizona), Guido Dalbagni, Sara M. Falzarano(University of South Florida), Jennifer Gordetsky(Bipar), Charles C. Guo(The University of Texas MD Anderson Cancer Center), Sounak Gupta(Mayo Clinic in Arizona), Ondřej Hes(Charles University), Gopa Iyer, Seema Kaushal(All India Institute of Medical Sciences), Lakshmi P. Kunju(University of Michigan), Cristina Magi‐Galluzzi(University of Alabama at Birmingham), Andrés Matoso, Jesse K. McKenney(Cleveland Clinic), George J. Netto(University of Alabama at Birmingham), Adeboye O. Osunkoya(Emory University), Chin Pan(Taipei Veterans General Hospital), Kristina Pivovarcikova(Charles University), Maria Rosaria Raspollini(Azienda Ospedaliero-Universitaria Careggi), Henning Reis(University of Duisburg-Essen), Jonathan E. Rosenberg(Memorial Sloan Kettering Cancer Center), Morgan Rouprêt(Sorbonne Université), Rajal B. Shah(The University of Texas Southwestern Medical Center), Shahrokh F. Shariat(Comprehensive Cancer Center Vienna), Kiril Trpkov(University of Calgary), Veronika Weyerer(Friedrich-Alexander-Universität Erlangen-Nürnberg), Ming Zhou(Tufts Medical Center), Victor Reuter
Advances in Anatomic Pathology
June 15, 2021
10.1097/pap.0000000000000309
Cited by 55

Abstract

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.

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