Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors
Bruno L. Cadilha(Center for Integrated Protein Science Munich), Mohamed-Reda Benmebarek(Center for Integrated Protein Science Munich), Klara Dorman(Center for Integrated Protein Science Munich), Arman Öner(Center for Integrated Protein Science Munich), Theo Lorenzini(Center for Integrated Protein Science Munich), Hannah Obeck(Center for Integrated Protein Science Munich), Mira Vänttinen(Center for Integrated Protein Science Munich), Mauro Di Pilato(The University of Texas MD Anderson Cancer Center), Jasper N. Pruessmann(Harvard University), Stefan Stoiber(Center for Integrated Protein Science Munich), Duc Huynh(Center for Integrated Protein Science Munich), Florian Märkl(Center for Integrated Protein Science Munich), Matthias Seifert(Center for Integrated Protein Science Munich), Katrin Manske(Center for Integrated Protein Science Munich), Javier Suárez-Gosálvez(Center for Integrated Protein Science Munich), Yi Zeng(Center for Integrated Protein Science Munich), Stefanie Lesch(Center for Integrated Protein Science Munich), Clara H. Karches(Center for Integrated Protein Science Munich), Constanze Heise(Center for Integrated Protein Science Munich), Adrian Gottschlich(Center for Integrated Protein Science Munich), Moritz Thomas(Helmholtz Zentrum München), Carsten Marr(Helmholtz Zentrum München), Jin Zhang(Center for Integrated Protein Science Munich), Dharmendra Pandey(Center for Integrated Protein Science Munich), Tobias Feuchtinger(German Center for Infection Research), Marion Subklewe(Ludwig-Maximilians-Universität München), Thorsten R. Mempel(Harvard University), Stefan Endres(Center for Integrated Protein Science Munich), Sebastian Kobold(Center for Integrated Protein Science Munich)
Cited by 100Open Access
Abstract
T cell recruitment to the tumor site. This sustained and improved infiltration of engineered T cells synergized with TGF-β shielding for improved therapeutic efficacy. Our results demonstrate that addition of CCR8 and DNR into CAR T cells can render them effective in solid tumors.
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