SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Elena Zavyalova(Lomonosov Moscow State University), Oganes Ambartsumyan(Sechenov University), Gleb Zhdanov(Lomonosov Moscow State University), Dmitry A. Gribanyov(Osipyan Institute of Solid State Physics RAS), Vladimir А. Gushchin(Gamalei Institute of Epidemiology and Microbiology), Artem P. Tkachuk(Gamalei Institute of Epidemiology and Microbiology), Елена В. Рудакова(Institute of Physiologically Active Compounds), Maria A. Nikiforova(Gamalei Institute of Epidemiology and Microbiology), Nadezhda A. Kuznetsova(Gamalei Institute of Epidemiology and Microbiology), Liubov I. Popova(Gamalei Institute of Epidemiology and Microbiology), Bakhtiyar I. Verdiev(Gamalei Institute of Epidemiology and Microbiology), Artem G. Alatyrev(Gamalei Institute of Epidemiology and Microbiology), Burtseva Ei(Gamalei Institute of Epidemiology and Microbiology), Anna V. Ignatieva(Gamalei Institute of Epidemiology and Microbiology), Anna A. Iliukhina(Gamalei Institute of Epidemiology and Microbiology), Inna V. Dolzhikova(Gamalei Institute of Epidemiology and Microbiology), Alexander M. Arutyunyan(Lomonosov Moscow State University), Alexandra Gambaryan, В. И. Кукушкин(Osipyan Institute of Solid State Physics RAS)
Nanomaterials
May 25, 2021
10.3390/nano11061394
Cited by 79Open Access
Full Text

Abstract

During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.

Related Papers

No related papers found

Powered by citation graph analysis