Unfractionated heparin reduces hepcidin levels in critically ill patients
Dimitrios Vagionas(National and Kapodistrian University of Athens), Marianna Politou(National and Kapodistrian University of Athens), Maria Kompoti(Thriasio General Hospital of Elefsina), Dimitrios‐Dorotheos Papadakis(National and Kapodistrian University of Athens), Eirini Kostakou(National and Kapodistrian University of Athens), Danai Theodoulou(National and Kapodistrian University of Athens), Evangelos Kaniaris(National and Kapodistrian University of Athens), Νikoletta Ρovina(National and Kapodistrian University of Athens), Antonia Koutsoukou(National and Kapodistrian University of Athens), Ioannis Vasileiadis(National and Kapodistrian University of Athens)
Cited by 4
Abstract
A strong anti-hepcidin activity has been observed in heparins. Mean hepcidin levels were significantly reduced compared to baseline, following the first day of unfractionated heparin administration in critically patients. Heparin displayed a strong independent negative association with hepcidin. These results may lead to future treatment methods of forms of anaemia characterised by hepcidin excess, common among the critically ill.
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