Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

De-Xuan Hu(Sun Yat-sen University), Lin‐Kun An(Sun Yat-sen University)

Journal of Medicinal Chemistry

May 19, 2021

10.1021/acs.jmedchem.1c00318

Cited by 28

Related Papers

Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity

|Bioorganic Chemistry|2022|11

Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors

|ChemMedChem|2023|10