COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Sheryl Ann Abdukahil(Angkor Hospital for Children), Ryuzo Abe(University of Oxford), Laurent Abel(University of Oxford), Lara Absil(University of Oxford), Andrew Acker(University of Oxford), Shingo Adachi(Angkor Hospital for Children), Elisabeth Adam(University of Oxford), Diana Adrião(University of Oxford), Kate Ainscough(University of Oxford), Ali Ait Hssain(University of Oxford), Younes Ait Tamlihat(University of Oxford), Takako Akimoto(University of Oxford), Tala Al-dabbous(University of Oxford), Abdulrahman Al‐Fares(University of Oxford), Eman Al Qasim(University of Oxford), Razi Alalqam(University of Oxford), Beatrice Alex(University of Oxford), Kévin Alexandre(University of Oxford), Huda Alfoudri(University of Oxford), Kazali Enagnon Alidjnou(University of Oxford), Jeffrey Aliudin(University of Oxford), Clotilde Allavena(University of Oxford), Nathalie Allou(University of Oxford), João Alves(University of Oxford), Rita Vieira Alves(University of Oxford), Maria Esméria Corezola do Amaral(University of Oxford), Heidi Ammerlaan(University of Oxford), Phoebe Ampaw(University of Oxford), Roberto Andini(University of Oxford), Claire Andréjak(University of Oxford), Andrea Angheben(University of Oxford), François Angoulvant(University of Oxford), Séverine Ansart(University of Oxford), Massimo Antonelli(University of Oxford), Carlos Alexandre Antunes de Brito(University of Oxford), Yaseen M. Arabi(University of Oxford), Irene Aragão(University of Oxford), Antonio Arcadipane(University of Oxford), Lukas Arenz(University of Oxford), Jean‐Benoît Arlet(University of Oxford), Christel Arnold-Day(University of Oxford), Lovkesh Arora(University of Oxford), Élise Artaud-Macari(University of Oxford), Ángel Asensio(University of Oxford), Jean‐Baptiste Assié(University of Oxford), Anika Atique(University of Oxford), Johann Auchabie(University of Oxford), Hugues Aumaître(University of Oxford), Laurène Azemar(University of Oxford), Cécile Azoulay(University of Oxford), Benjamin Bach(University of Oxford), Delphine Bachelet(University of Oxford), J. Kenneth Baillie(University of Oxford), Erica Bak(University of Oxford), Agamemnon Bakakos(University of Oxford), Firouzé Bani‐Sadr(University of Oxford), Renata Barbalho(University of Oxford), William Barclay(University of Oxford), Michaela Barnikel(University of Oxford), Audrey Barrelet(University of Oxford), Cleide Barrigoto(University of Oxford), Romain Basmaci(University of Oxford), Diego Fernando Bautista Rincón(University of Oxford), Alexandra Bedossa(University of Oxford), Sylvie Behilill(University of Oxford), Aleksandr Beljantsev(University of Oxford), David Bellemare(University of Oxford), Anna Beltrame(University of Oxford), Marine Beluze(University of Oxford), Nicolas Benech(University of Oxford), Dehbia Benkerrou(University of Oxford), Suzanne Bennett(University of Oxford), Luís Bento(University of Oxford), Jan‐Erik Berdal(University of Oxford), Delphine Bergeaud(University of Oxford), Lorenzo Bertolino(University of Oxford), Simon Bessis(University of Oxford), Sybille Bevilcaqua(University of Oxford), Krishna Bhavsar(University of Oxford), Felwa Bin Humaid(University of Oxford), François Bissuel(University of Oxford), Patrick Biston(University of Oxford), Laurent Bitker(University of Oxford), Pablo Blanco-Schweizer(University of Oxford), Mathieu Blot(University of Oxford), Filomena Boccia(University of Oxford), Debby Bogaert(University of Oxford), François Bompart(University of Oxford), Gareth Booth(University of Oxford), Diogo Borges(University of Oxford), Raphaël Borie(University of Oxford), Jeannet C. Bos(University of Oxford), Hans Martin Bosse(University of Oxford), Élisabeth Botelho-Nevers(University of Oxford), Lila Bouadma(University of Oxford), Olivier Bouchaud(University of Oxford), Sabelline Bouchez(University of Oxford), Dounia Bouhmani(University of Oxford), Damien Bouhour(University of Oxford), Kévin Bouiller(University of Oxford), Laurence Bouillet(University of Oxford), Camille Bouisse(University of Oxford), Anne‐Sophie Boureau(University of Oxford), Maude Bouscambert(University of Oxford), Jason Bouziotis(University of Oxford), Bianca Boxma(University of Oxford), Marielle Boyer-Besseyre(University of Oxford), Maria Boylan(University of Oxford), Cynthia Braga(University of Oxford), Timo Brandenburger(University of Oxford), Luca Brazzi(University of Oxford), Dorothy Breen(University of Oxford), Patrick J. Breen(University of Oxford), Kathy Brickell(University of Oxford), Nicolas Brozzi(University of Oxford), Nina Buchtele(University of Oxford), Christian Buesaquillo(University of Oxford), Polina Bugaeva(University of Oxford), Marielle Buisson(University of Oxford), Erlina Burhan(University of Oxford), Ingrid G. Bustos(University of Oxford), Denis Butnaru(University of Oxford), Sheila Cárcel(University of Oxford), André Cabie(University of Oxford), Susana Cabral(University of Oxford), Eder Cáceres(University of Oxford), Mia Callahan(University of Oxford), Kate Calligy(University of Oxford), Jose Andres Calvache(University of Oxford), João Camões(University of Oxford), Valentine Campana(University of Oxford), Paul Campbell(University of Oxford), Cecilia Canepa(University of Oxford), Mireia Cantero(University of Oxford), Pauline Caraux-Paz(University of Oxford), Filipa Cardoso(University of Oxford), Filipe S. Cardoso(University of Oxford), Sofia Cardoso(University of Oxford), Simone Carelli(University of Oxford), Nicolas Carlier(University of Oxford), Gayle Carney(University of Oxford), Chloe Carpenter(University of Oxford), Marie-Christine Carret(University of Oxford), François Martin Carrier(University of Oxford), Gail Carson(University of Oxford), Maire-Laure Casanova(University of Oxford), Mariana Cascão(University of Oxford), José Casimiro(University of Oxford), Bailey Cassandra(University of Oxford), Silvia Castañeda(University of Oxford), Nidyanara Castanheira(University of Oxford), Guylaine Castor-Alexandre(University of Oxford), Henry Castrillón(University of Oxford), Ivo Castro(University of Oxford), Ana Catarino(University of Oxford), François-Xavier Catherine(University of Oxford), Roberta Figueiredo Cavalin(University of Oxford), Giulio Giovanni Cavalli(University of Oxford), Alexandros Cavayas(University of Oxford), Adrián Ceccato(University of Oxford), Minerva Cervantes-Gonzalez(University of Oxford), Anissa Chair(University of Oxford), Catherine Chakveatze(University of Oxford), Adrienne K Chan(University of Oxford), Meera Chand(University of Oxford), Julie Chas(University of Oxford), Camille Chassin(University of Oxford), Anjellica Chen(University of Oxford), Yih‐Sharng Chen(University of Oxford), Matthew Pellan Cheng(University of Oxford), Antoine Chéret(University of Oxford), Thibault Chiarabini(University of Oxford), Julián Chica(University of Oxford), Catherine Chirouze(University of Oxford), Davide Chiumello(University of Oxford), Hwa Jin Cho(University of Oxford), Sung‐Min Cho(University of Oxford), Bernard Cholley(University of Oxford), José Pedro Cidade(University of Oxford), José Miguel Cisneros(University of Oxford), Barbara Wanjiru Citarella(University of Oxford), Anna Ciullo(University of Oxford), Jennifer Clarke(University of Oxford), Sara Clohisey(University of Oxford), Cassidy Codan(University of Oxford), Caitriona Cody(University of Oxford), Alexandra Coelho(University of Oxford), Gwenhaël Colin(University of Oxford), Michael Collins(University of Oxford), Sebastiano Maria Colombo(University of Oxford), Pamela Combs(University of Oxford), J. P. Connelly(University of Oxford), Marie Connor(University of Oxford), Anne Conrad(University of Oxford), Sofía Contreras(University of Oxford), G Cooke(University of Oxford), Mary Copland(University of Oxford), Hugues Cordel(University of Oxford), Amanda Corley(University of Oxford), Sarah Cormican(University of Oxford), Sabine Cornelis(University of Oxford), Arianne Joy Corpuz(University of Oxford), Grégory Corvaisier(University of Oxford), Camille Couffignal(University of Oxford), Sandrine Couffin-Cadièrgues(University of Oxford), Roxane Courtois(University of Oxford), Charles Crepy D’Orleans(University of Oxford), Sabine Croonen(University of Oxford), Gloria Crowl(University of Oxford), Jonathan Crump(University of Oxford), Claudina Cruz(University of Oxford), Marc Csete(University of Oxford), Alberto Cucino(University of Oxford), Caroline Cullen(University of Oxford), Matthew J. Cummings(University of Oxford), Gerard F. Curley(University of Oxford), Elodie Curlier(University of Oxford), Paula Custódio(University of Oxford), Frédérick D’Aragon(University of Oxford), Ana da Silva Filipe(University of Oxford), Charlène Da Silveira(University of Oxford), Éric D’Ortenzio(University of Oxford), Al-Awwab Dabaliz(University of Oxford), Andrew Dagens(University of Oxford), Heidi J. Dalton(University of Oxford), Jo Ann Dalton(University of Oxford), Nick Daneman(University of Oxford), Emmanuelle A. Dankwa(University of Oxford), Jorge Dantas(University of Oxford), Nathalie De Castro(University of Oxford), Diego de Mendoza(University of Oxford), Rafael Freitas de Oliveira França(University of Oxford), Rosanna Carmela De Rosa(University of Oxford), Thushan I. de Silva(University of Oxford), Peter de Vries(University of Oxford), David A. Dean(University of Oxford), Marie‐Pierre Debray(University of Oxford), William Dechert(University of Oxford), Lauren Deconninck(University of Oxford), Romain Decours(University of Oxford), Isabelle Delacroix(University of Oxford), K. Delavigne(University of Oxford), Ionna Deligiannis(University of Oxford), Andrea Dell’Amore(University of Oxford), Pierre Delobel(University of Oxford), Élisa Demonchy(University of Oxford), Emmanuelle Denis(University of Oxford), Dominique Deplanque(University of Oxford), Pieter Depuydt(University of Oxford), Mehul J. Desai(University of Oxford), Diane Descamps(University of Oxford), Mathilde Desvallée(University of Oxford), Santi Rahayu Dewayanti(University of Oxford), Alpha Diallo(University of Oxford), Sylvain Diamantis(University of Oxford), André Ivan Bradley dos Santos Dias(University of Oxford), Juan Jose Diaz Diaz(University of Oxford), R. F. Díaz(University of Oxford), Kévin Didier(University of Oxford), Jean‐Luc Diehl(University of Oxford), Wim Dieperink(University of Oxford), Jérôme Dimet(University of Oxford), Vincent Dinot(University of Oxford), Alphonsine Diouf(University of Oxford), Yael Dishon(University of Oxford), Félix Djossou(University of Oxford), Annemarie B Docherty(University of Oxford), Andy Dong(University of Oxford), Christl A. Donnelly(University of Oxford), Maria Donnelly(University of Oxford), Chloe Donohue(University of Oxford), Céline Dorival(University of Oxford), James Joshua Douglas(University of Oxford), Renée Douma(University of Oxford), Nathalie Dournon(University of Oxford), Triona Downer(University of Oxford), Mark Downing(University of Oxford), Tom Drake(University of Oxford), Vincent Dubée(University of Oxford), François Dubos(University of Oxford), Alexandra Ducancelle(University of Oxford), Susanne Dudman(University of Oxford), Jake Dunning(University of Oxford), Emanuele Durante‐Mangoni(University of Oxford), Silvia Duranti(University of Oxford), Lucian A. Durham(University of Oxford), Bertrand Dussol(University of Oxford), Xavier Duval(University of Oxford), Anne Margarita Dyrhol-Riise(University of Oxford), Carla Eira(University of Oxford), José Ernesto Vidal(University of Oxford), Mohammed El Sanharawi(University of Oxford), Subbarao Elapavaluru(University of Oxford), Brigitte Elharrar(University of Oxford), Natalie Elkheir(University of Oxford), Jacobien Ellerbroek(University of Oxford), Rachael Ellis(University of Oxford), Philippine Eloy(University of Oxford), Tarek M. Elshazly(University of Oxford), Isabelle Enderle(University of Oxford), Ilka Engelmann(University of Oxford), Vincent Enouf(University of Oxford), Olivier Épaulard(University of Oxford), Mariano Esperatti(University of Oxford), Hélène Espérou(University of Oxford), Marina Esposito‐Farèse(University of Oxford), Jo�ão Estêv�ão(University of Oxford), Manuel Etienne(University of Oxford), Manuel Etienne(University of Oxford), Nadia Ettalhaoui(University of Oxford), Anna Greti Everding(University of Oxford), Mirjam Evers(University of Oxford), Isabelle Fabre(University of Oxford), Amna Faheem(University of Oxford), Arabella Fahy(University of Oxford), Cameron J. Fairfield(University of Oxford), P. Olívio Gosuen De Faria(University of Oxford), Nataly Farshait(University of Oxford), Arie Zainul Fatoni(University of Oxford), Karine Faure(University of Oxford), Mohamed Fayed(University of Oxford), Niamh Feely(University of Oxford), Jorge Fernandes(University of Oxford), Marília Andreia Fernandes(University of Oxford), S. Fernandes(University of Oxford), Joana Ferrão(University of Oxford), Eglantine Ferrand Devouge(University of Oxford), Mário Ferraz(University of Oxford), Benigno Ferreira(University of Oxford), Ricard Ferrer(University of Oxford), Claudia Figueiredo-Mello(University of Oxford), C. Flateau(University of Oxford), Tom Fletcher(University of Oxford), Letizia Lucia Florio(University of Oxford), Claire Foley(University of Oxford), Victor Fomin(University of Oxford), Cláudio Duarte Fonseca(University of Oxford), Tatiana Fonseca(University of Oxford), Patricia Fontela(University of Oxford), Simon Forsyth(University of Oxford), Giuseppe Foti(University of Oxford), Erwan Fourn(University of Oxford), Rob Fowler(University of Oxford), Diego Franch-Llasat(University of Oxford), Christophe Fraser(University of Oxford), John F. Fraser(University of Oxford), Marcela Vieira Freire(University of Oxford), Ana Freitas Ribeiro(University of Oxford), Caren Friedrich(University of Oxford), Stéphane Fry(University of Oxford), Nora Fuentes(University of Oxford), Masahiro Fukuda(University of Oxford), Joan Gómez‐Junyent(University of Oxford), Valérie Gaborieau(University of Oxford), Benoît Gachet(University of Oxford), Rostane Gaci(University of Oxford), Massimo Gagliardi(University of Oxford), Jean-Charles Gagnard(University of Oxford), Amandine Gagneux‐Brunon(University of Oxford), Sérgio Gaião(University of Oxford), Phil Gallagher(University of Oxford), Elena Gallego Curto(University of Oxford), Carrol Gamble(University of Oxford), A.R. Garan(University of Oxford), Esteban García-Gallo(University of Oxford), Rebekha Garcia(University of Oxford), Denis Garot(University of Oxford), Valérie Garrait(University of Oxford), Nathalie Gault(University of Oxford), Aisling Gavin(University of Oxford), Alexandre Gaymard(University of Oxford), Johannes Gebauer(University of Oxford), Louis Gerbaud Morlaes(University of Oxford), Nuno Germano(University of Oxford), Jade Ghosn(University of Oxford), Marco Giani(University of Oxford), Carlo Giaquinto(University of Oxford), Jess Gibson(University of Oxford), Tristan Gigante(University of Oxford), Morgane Gilg(University of Oxford), Guillermo Giordano(University of Oxford), Michelle Girvan(University of Oxford), Valérie Gissot(University of Oxford), Gezy Giwangkancana(University of Oxford), Daniel Glikman(University of Oxford), Petr Glybochko(University of Oxford), Eric Gnall(University of Oxford), Geraldine Goco(University of Oxford), François Goehringer(University of Oxford), Siri Goepel(University of Oxford), Jean‐Christophe Goffard(University of Oxford), Jonathan L. Golob(University of Oxford), Isabelle Gorenne(University of Oxford), Cécile Goujard(University of Oxford), Tiphaine Goulenok(University of Oxford), Margarite Grable(University of Oxford), E. Wilson Grandin(University of Oxford), Pascal Granier(University of Oxford), Giacomo Grasselli(University of Oxford), Christopher Green(University of Oxford), William Greenhalf(University of Oxford), S. Greffe(University of Oxford), Domenico Luca Grieco(University of Oxford), Matthew Griffee(University of Oxford), Fiona Griffiths(University of Oxford), Ioana Grigoraș(University of Oxford), Albert Groenendijk(University of Oxford), Anja Große Lordemann(University of Oxford), Heidi Gruner(University of Oxford), Yusing Gu(University of Oxford), Jérémie Guedj(University of Oxford), Dewi Guellec(University of Oxford), Anne‐Marie Guerguerian(University of Oxford), Daniela Guerreiro(University of Oxford), Romain Guéry(University of Oxford), Anne Guillaumot(University of Oxford), Laurent Guilleminault(University of Oxford), Thomas Guimard(University of Oxford), Daniel A. Haber(University of Oxford), Sheeba Hakak(University of Oxford), Matthew Hall(University of Oxford), Sophie Halpin(University of Oxford), Ansley Hamer(University of Oxford), Rébecca Hamidfar(University of Oxford), Terese Hammond(University of Oxford), Hayley Hardwick(University of Oxford), Kristen Harley(University of Oxford), Ewen M. Harrison(University of Oxford), Janet Harrison(University of Oxford), Leanne Hays(University of Oxford), Jan Heerman(University of Oxford), Lars Heggelund(University of Oxford), Ross Hendry(University of Oxford), Martina Hennessy(University of Oxford), Aquiles R. Henríquez-Trujillo(University of Oxford), Maxime Hentzien(University of Oxford), Jaime Hernández-Montfort(University of Oxford), Astarini Hidayah(University of Oxford), Dawn Higgins(University of Oxford), Eibhilin Higgins(University of Oxford), Samuel Hinton(University of Oxford), Ana Hipólito-Reis(University of Oxford), Hiroaki Hiraiwa(University of Oxford), Julian A. Hiscox(University of Oxford), Antonia Ho(University of Oxford), Alexandre Hoctin(University of Oxford), Isabelle Hoffmann(University of Oxford), Oscar Hoiting(University of Oxford), Rebecca Holt(University of Oxford), Jan Cato Holter(University of Oxford), Peter Horby(University of Oxford), Juan Pablo Horcajada(University of Oxford), Koji Hoshino(University of Oxford), Kota Hoshino(University of Oxford), Catherine L. Hough(University of Oxford), Jimmy Ming-Yang Hsu(University of Oxford), Jean‐Sébastien Hulot(University of Oxford), Samreen Ijaz(University of Oxford), Hajnal-Gabriela Illes(University of Oxford), Hugo Inácio(University of Oxford), Carmen Infante Dominguez(University of Oxford), Εlias Iosifidis(University of Oxford), Lacey Irvine(University of Oxford), Sarah Isgett(University of Oxford), Tiago Isidoro(University of Oxford), Margaux Isnard(University of Oxford), Junji Itai(University of Oxford), Daniel Ivulich(University of Oxford), Salma Jaafoura(University of Oxford), Julien Jabot(University of Oxford), Clare Jackson(University of Oxford), Nina Jamieson(University of Oxford), Stéphane Jauréguiberry(University of Oxford), Jeffrey Javidfar(University of Oxford), Zabbe Jean-Benoît(University of Oxford), Florence Jego(University of Oxford), Synne Jenum(University of Oxford), Ruth Jimbo-Sotomayor(University of Oxford), Ruth Noemí Jorge GarcÍa(University of Oxford), Cédric Joseph(University of Oxford), Mark Joseph(University of Oxford), Philippe Jouvet(University of Oxford), Hanna Jung(University of Oxford), Ouifiya Kafif(University of Oxford), Florentia Kaguelidou(University of Oxford), Sabina Kali(University of Oxford), Smaragdi Kalomoiri(University of Oxford), Darshana Hewa Kandamby(University of Oxford), Christopher Kandel(University of Oxford), Ravi Kant(University of Oxford), Christiana Kartsonaki(University of Oxford), Daisuke Kasugai(University of Oxford), Kevin Katz(University of Oxford), Simreen Kaur Johal(University of Oxford), Seán Keating(University of Oxford), Andrea Kelly(University of Oxford), Sadie Kelly(University of Oxford), Lisa Kennedy(University of Oxford), Kalynn Kennon(University of Oxford), Younes Kerroumi(University of Oxford), Evelyne Kestelyn(University of Oxford), Imrana Khalid(University of Oxford), Antoine Khalil(University of Oxford), Coralie Khan(University of Oxford), Irfan Ullah Khan(University of Oxford), Michelle E. Kho(University of Oxford), Saye Khoo(University of Oxford), Yuri Kida(University of Oxford), Peter Kiiza(University of Oxford), Anders Benjamin Kildal(University of Oxford), Antoine Kimmoun(University of Oxford), Detlef Kindgen‐Milles(University of Oxford), Nobuya Kitamura(University of Oxford), Paul Klenerman(University of Oxford), Gry Kloumann Bekken(University of Oxford), Stephen R Knight(University of Oxford), Robin Kobbe(University of Oxford), Malte Kohns Vasconcelos(University of Oxford), Volkan Korten(University of Oxford), Caroline Kosgei(University of Oxford), Karolina Krawczyk(University of Oxford), Pavan Kumar Vecham(University of Oxford), Deepali Kumar(University of Oxford), Ethan Kurtzman(University of Oxford), Demetrios J. Kutsogiannis(University of Oxford), Konstantinos G. Kyriakoulis(University of Oxford), Erwan L’Her(University of Oxford), Marie Lachâtre(University of Oxford), Marie Lacoste(University of Oxford), John G. Laffey(University of Oxford), Marie Lagrange(University of Oxford), Fabrice Laine(University of Oxford), Marc Lambert(University of Oxford), François Lamontagne(University of Oxford), Marie Langelot-Richard(University of Oxford), Eka Yudha Lantang(University of Oxford), Marina Lanza(University of Oxford), Cédric Laouenan(University of Oxford), Samira Laribi(University of Oxford), Delphine Larivière(University of Oxford), Odile Launay(University of Oxford), Yoan Lavie‐Badie(University of Oxford), Andrew Law(University of Oxford), Clément Le Bihan(University of Oxford), Cyril Le Bris(University of Oxford), Eve Le Coustumier(University of Oxford), Georges Le Falher(University of Oxford), Sylvie Le Gac(University of Oxford), Quentin Le Hingrat(University of Oxford), Marion Le Maréchal(University of Oxford), Soizic Le Mestre(University of Oxford), Vincent Le Moing(University of Oxford), Hervé Le Nagard(University of Oxford), Paul Le Turnier(University of Oxford), Rafael León(University of Oxford), Minh Le(University of Oxford), Marta Santos(University of Oxford), Ema Leal(University of Oxford), James Lee(University of Oxford), Su Hwan Lee(University of Oxford), Todd A. Lee(University of Oxford), Gary Leeming(University of Oxford), Bénédicte Lefebvre(University of Oxford), Laurent Lefèbvre(University of Oxford), Benjamin Lefèvre(University of Oxford), François Lellouche(University of Oxford), Adrien Lemaignen(University of Oxford), Véronique Lemee(University of Oxford), Gretchen Lemmink(University of Oxford), Michela Leone(University of Oxford), Quentin Lepiller(University of Oxford), François-Xavier Lescure(University of Oxford), O. Lesens(University of Oxford), Mathieu Lesouhaitier(University of Oxford), Claire Lévy‐Marchal(University of Oxford), Bruno Lévy(University of Oxford), Yves Lévy(University of Oxford), Gianluigi Li Bassi(University of Oxford), Janet Liang(University of Oxford), Wei Shen Lim(University of Oxford), Bruno Lina(University of Oxford), Andreas Lind(University of Oxford), Guillaume Lingas(University of Oxford), Sylvie Lion-Daolio(University of Oxford), Keibun Liu(University of Oxford), Antonio Loforte(University of Oxford), Navy Lolong(University of Oxford), Diogo Lopes(University of Oxford), Dalia López‐Colón(University of Oxford), Paul Loubet(University of Oxford), Jean Christophe Lucet(University of Oxford), Carlos M. Luna(University of Oxford), Olguța Lungu(University of Oxford), Liem Luong(University of Oxford), Dominique Luton(University of Oxford), Ruth Lyons(University of Oxford), Fredrik Müller(University of Oxford), Karl Erik Müller(University of Oxford), Olavi Maasikas(University of Oxford), Sarah MacDonald(University of Oxford), Moïse Machado(University of Oxford), G. Macheda(University of Oxford), Juan Macías Sánchez(University of Oxford), Jai Madhok(University of Oxford), Rafaël Mahieu(University of Oxford), Sophie Mahy(University of Oxford), Lars S. Maier(University of Oxford), Mylène Maillet(University of Oxford), Thomas Maitre(University of Oxford), Maximilian Malfertheiner(University of Oxford), Nadia Shamshad Malik(University of Oxford), Fernando Maltêz(University of Oxford), Denis Malvy(University of Oxford), Marina Mambert(University of Oxford), Victoria Manda(University of Oxford), Jose M. Mandei(University of Oxford), Edmund Manning(University of Oxford), Aldric Manuel(University of Oxford), Ceila Maria Sant(University of Oxford), Ana Malaque(University of Oxford), Flávio Marino(University of Oxford), Carolline Araujo(University of Oxford), Charbel Maroun‐Eid(University of Oxford), Ana Marques(University of Oxford), Catherine Marquis(University of Oxford), Brian Marsh(University of Oxford), Laura Marsh(University of Oxford), John Marshall(University of Oxford), Celina Maria Turchi Martelli(University of Oxford), Guillaume Martin‐Blondel(University of Oxford), Ignacio Martín‐Loeches(University of Oxford), Alejandro Martín‐Quirós(University of Oxford), Dori-Ann Martin(University of Oxford), Emily Martin(University of Oxford), M. Martinot(University of Oxford), Caroline Martins Rego(University of Oxford), Ana Martins(University of Oxford), João Martins(University of Oxford), Gennaro Martucci(University of Oxford), Eva Miranda Marwali(University of Oxford), Juan Fernado Masa Jimenez(University of Oxford), David M. Maslove(University of Oxford), Sabina Mason(University of Oxford), Moshe Matan(University of Oxford), Daniel Mathieu(University of Oxford), Mathieu Mattèi(University of Oxford), Romans Matulevics(University of Oxford), Laurence Maulin(University of Oxford), Natalie Mc Evoy(University of Oxford), Aine McCarthy(University of Oxford), Colin McCloskey(University of Oxford), Rachael McConnochie(University of Oxford), Sherry McDermott(University of Oxford), Sarah McDonald(University of Oxford), Samuel McElwee(University of Oxford), Natalie McEvoy(University of Oxford), Allison McGeer(University of Oxford), Niki McGuinness(University of Oxford), Kenneth A McLean(University of Oxford), Bairbre McNicholas(University of Oxford), Edel Meaney(University of Oxford), Cécile Mear-Passard(University of Oxford), Maggie Mechlin(University of Oxford), Ferruccio Mele(University of Oxford), Kusum Menon(University of Oxford), France Mentré(University of Oxford), Alexander J. Mentzer(University of Oxford), Noémie Mercier(University of Oxford), Antoine Merckx(University of Oxford), Blake Mergler(University of Oxford), Laura Merson(University of Oxford), António Pedro Mesquita(University of Oxford), Agnès Meybeck(University of Oxford), Alison Meynert(University of Oxford), Vanina Meyssonnier(University of Oxford), Amina Meziane(University of Oxford), Medhi Mezidi(University of Oxford), Céline Michelanglei(University of Oxford), Vladislav Mihnovitš(University of Oxford), Hugo Miranda Maldonado(University of Oxford), Mary C. Mone(University of Oxford), Asma Moin(University of Oxford), David Molina(University of Oxford), Elena Molinos(University of Oxford), Agostinho Monteiro(University of Oxford), Claudia Montes(University of Oxford), Giorgia Montrucchio(University of Oxford), Sarah Moore(University of Oxford), Shona C. Moore(University of Oxford), Lina Morales-Cely(University of Oxford), Lucía Moro(University of Oxford), Diego Rolando Morocho Tutillo(University of Oxford), Ana Motos(University of Oxford), Hugo Mouquet(University of Oxford), Clara Mouton Perrot(University of Oxford), Julien Moyet(University of Oxford), Jimmy Mullaert(University of Oxford), Daniel Munblit(University of Oxford), Derek Murphy(University of Oxford), Marlène Murris(University of Oxford), Dimitra Melia Myrodia(University of Oxford), Yohan N’Guyen(University of Oxford), Nadège Néant(University of Oxford), Holger Neb(University of Oxford), Nikita Nekliudov(University of Oxford), Raul Neto(University of Oxford), Emily Neumann(University of Oxford), Bernardo Neves(University of Oxford), Pauline Yeung Ng(University of Oxford), Wing Yiu Ng(University of Oxford), Orna Ní Choileáin(University of Oxford), Alistair Nichol(University of Oxford), Stephanie Nonas(University of Oxford), Marion Noret(University of Oxford), Lisa Norman(University of Oxford), Alessandra Notari(University of Oxford), Mahdad Noursadeghi(University of Oxford), Karolina Nowicka(University of Oxford), Saad Nseir(University of Oxford), Jose I. Nunez(University of Oxford), Elsa Nyamankolly(University of Oxford), Max R. O’Donnell(University of Oxford), Katie O’Hearn(University of Oxford), Conar O’Neil(University of Oxford), Giovanna Occhipinti(University of Oxford), Tawnya Ogston(University of Oxford), Takayuki Ogura(University of Oxford), Tak-Hyuk Oh(University of Oxford), Shinichiro Ohshimo(University of Oxford), Budha Charan Singh Oinam(University of Oxford), Ana Pinho Oliveira(University of Oxford), J.P. Oliveira(University of Oxford), Piero Olliaro(University of Oxford), David S. Y. Ong(University of Oxford), Wilna Oosthuyzen(University of Oxford), Peter J. M. Openshaw(University of Oxford), Claudia Milena Orozco‐Chamorro(University of Oxford), Andrés Orquera(University of Oxford), Javier Osatnik(University of Oxford), Nadia Ouamara(University of Oxford), Rachida Ouissa(University of Oxford), Clark G. Owyang(University of Oxford), E. Oziol(University of Oxford), Diana Póvoas(University of Oxford), Maïder Pagadoy(University of Oxford), Justine Pages(University of Oxford), Mario Palacios(University of Oxford), Massimo Palmarini(University of Oxford), Giovanna Panarello(University of Oxford), Prasan Kumar Panda(University of Oxford), Mauro Panigada(University of Oxford), Nathalie Pansu(University of Oxford), Aurélie Papadopoulos(University of Oxford), Briseida Parra(University of Oxford), Jérémie Pasquier(University of Oxford), Fabian Patauner(University of Oxford), Luís Patrão(University of Oxford), Christelle Paul(University of Oxford), Mical Paul(University of Oxford), Jorge Paulos(University of Oxford), William A. Paxton(University of Oxford), Jean‐François Payen(University of Oxford), India Pearse(University of Oxford), Giles J. Peek(University of Oxford), Florent Peelman(University of Oxford), Nathan Peiffer‐Smadja(University of Oxford), Vincent Peigne(University of Oxford), Mare Pejkovska(University of Oxford), Ithan D. Peltan(University of Oxford), Rui Pereira(University of Oxford), Daniel Pérez(University of Oxford), Thomas Perpoint(University of Oxford), Antonio Artigas(University of Oxford), Lenka Petroušová(University of Oxford), Ventzislava Petrov-Sanchez(University of Oxford), Gilles Peytavin(University of Oxford), Scott Pharand(University of Oxford), Michaël Piagnerelli(University of Oxford), Walter Picard(University of Oxford), Olivier Picone(University of Oxford), Marie Piel-Julian(University of Oxford), Carola Pierobon(University of Oxford), Carlos Pimentel(University of Oxford), Lionel Piroth(University of Oxford), Riinu Pius(University of Oxford), Simone Piva(University of Oxford), Laurent Plantier(University of Oxford), Daniel Plotkin(University of Oxford), Julien Poissy(University of Oxford), Maria Pokorska‐Śpiewak(University of Oxford), Sergio Poli(University of Oxford), Georgios Pollakis(University of Oxford), Jolanta Popielska(University of Oxford), Douwe F. Postma(University of Oxford), Pedro Póvoa(University of Oxford), Jeff Powis(University of Oxford), Sofia Prapa(University of Oxford), Christian Prebensen(University of Oxford), Jean‐Charles Preiser(University of Oxford), Vincent Prestre(University of Oxford), Nicholas Price(University of Oxford), Anton Prinssen(University of Oxford), Mark G. Pritchard(University of Oxford), Lúcia Proença(University of Oxford), Oriane Puéchal(University of Oxford), Gregory Purcell(University of Oxford), Luisa Quesada(University of Oxford), Else Quist‐Paulsen(University of Oxford), Mohammed Quraishi(University of Oxford), Indrek Rätsep(University of Oxford), Bernhard Rössler(University of Oxford), Christian Rabaud(University of Oxford), Marie Rafiq(University of Oxford), Gabrielle Ragazzo(University of Oxford), Fernando Rainieri(University of Oxford), Nagarajan Ramakrishnan(University of Oxford), Kollengode Ramanathan(University of Oxford), Blandine Rammaert(University of Oxford), C. Rapp(University of Oxford), Menaldi Rasmin(University of Oxford), Cornelius Rau(University of Oxford), Stanislas Rebaudet(University of Oxford), Sarah Redl(University of Oxford), Brenda Reeve(University of Oxford), Liadain Reid(University of Oxford), Renato Barbosa Reis(University of Oxford), Jonathan Remppis(University of Oxford), Martine Rémy(University of Oxford), Hanna Renk(University of Oxford), Liliana Resende(University of Oxford), Anne-Sophie Resseguier(University of Oxford), Matthieu Revest(University of Oxford), Oleksa Rewa(University of Oxford), Luis Felipe Reyes(University of Oxford), David Richardson(University of Oxford), Denise Richardson(University of Oxford), Laurent Richier(University of Oxford), Jordi Riera(University of Oxford), Ana Lúcia Rios(University of Oxford), Asgar Rishu(University of Oxford), P Rispal(University of Oxford), Karine Risso(University of Oxford), María Angélica Rivera Núñez(University of Oxford), Nicholas Rizer(University of Oxford), André Roberto(University of Oxford), Stephanie Roberts(University of Oxford), David Robertson(University of Oxford), Olivier Robineau(University of Oxford), Ferran Roche‐Campo(University of Oxford), Paola Rodari(University of Oxford), Simão Rodeia(University of Oxford), Julia Rodriguez Abreu(University of Oxford), Emmanuel Roilides(University of Oxford), Amanda Rojek(University of Oxford), Juliette Romaru(University of Oxford), Roberto Roncon‐Albuquerque(University of Oxford), Mélanie Roriz(University of Oxford), Manuel Rosa‐Calatrava(University of Oxford), Michael Rose(University of Oxford), Dorothea Rosenberger(University of Oxford), Andrea Rossanese(University of Oxford), Bénédicte Rossignol(University of Oxford), Patrick Rossignol(University of Oxford), Carine Roy(University of Oxford), Benoît Rozé(University of Oxford), Clark D. Russell(University of Oxford), Steffi Ryckaert(University of Oxford), Aleksander Rygh Holten(University of Oxford), Xavier Sánchez(University of Oxford), Isabela Saba(University of Oxford), Musharaf Sadat(University of Oxford), Nadia Saïdani(University of Oxford), Leonardo Salazar(University of Oxford), Gabriele Sales(University of Oxford), Stéphane Sallaberry(University of Oxford), Hélène Salvator(University of Oxford), Ángel Sánchez-Miralles(University of Oxford), Olivier Sanchez(University of Oxford), Vanessa Sancho‐Shimizu(University of Oxford), Gyan Sandhu(University of Oxford), Oana Săndulescu(University of Oxford), Marlene Santos(University of Oxford), Shirley Sarfo-Mensah(University of Oxford), Benjamine Sarton(University of Oxford), Egle Saviciute(University of Oxford), Parthena Savvidou(University of Oxford), Joshua Scarsbrook(University of Oxford), Tjard Schermer(University of Oxford), Arnaud Scherpereel(University of Oxford), Marion Schneider(University of Oxford), Stephan Schroll(University of Oxford), Michael Schwameis(University of Oxford), James Scott-Brown(University of Oxford), J. T. Scott(University of Oxford), Nicholas Sédillot(University of Oxford), Tamara Seitz(University of Oxford), Caroline Semaille(University of Oxford), Malcolm G. Semple(University of Oxford), Eric Senneville(University of Oxford), Filipa Sequeira(University of Oxford), Tânia Sequeira(University of Oxford), Ellen Shadowitz(University of Oxford), Mohammad Shamsah(University of Oxford), Pratima Sharma(University of Oxford), Catherine A. Shaw(University of Oxford), Victoria Shaw(University of Oxford), Nisreen Shiban(University of Oxford), Nobuaki Shime(University of Oxford), Hiroaki Shimizu(University of Oxford), Keiki Shimizu(University of Oxford), Sally Shrapnel(University of Oxford), Hoi‐Ping Shum(University of Oxford), Nassima Si Mohammed(University of Oxford), Louise Sigfrid(University of Oxford), Catarina Silva(University of Oxford), Maria João Silva(University of Oxford), Wai Ching Sin(University of Oxford), Vegard Skogen(University of Oxford), Sue Smith(University of Oxford), Benjamin Smood(University of Oxford), Michelle Smyth(University of Oxford), Morgane Snacken(University of Oxford), Dominic So(University of Oxford), Monserrat Solis(University of Oxford), Joshua Solomon(University of Oxford), Tom Solomon(University of Oxford), Emily C. Somers(University of Oxford), Agnès Sommet(University of Oxford), Myung Jin Song(University of Oxford), Rima Song(University of Oxford), Tae Jin Song(University of Oxford), Michael Sonntagbauer(University of Oxford), Edouard Soum(University of Oxford), Maria Sousa Uva(University of Oxford), Marta Sousa(University of Oxford), Vicente Cés de Souza-Dantas(University of Oxford), Alexandra Sperry(University of Oxford), Shiranee Sriskandan(University of Oxford), Thomas Staudinger(University of Oxford), Stephanie-Susanne Stecher(University of Oxford), Ymkje Stienstra(University of Oxford), Birgitte Stiksrud(University of Oxford), Adrian Streinu‐Cercel(University of Oxford), Anca Streinu‐Cercel(University of Oxford), Samantha Strudwick(University of Oxford), Ami Stuart(University of Oxford), David I. Stuart(University of Oxford), Asfia Sultana(University of Oxford), Charlotte Summers(University of Oxford), Magdalena Surovcová Andrey A. Svistunov(University of Oxford), Konstantinos Syrigos(University of Oxford), Jaques Sztajnbok(University of Oxford), Konstanty Szułdrzyński(University of Oxford), François Téoulé(University of Oxford), Shirin Tabrizi(University of Oxford), Lysa Tagherset(University of Oxford), Ewa Talarek(University of Oxford), Sara Taleb(University of Oxford), Jelmer Talsma(University of Oxford), Tan Le Van(University of Oxford), Hiroyuki Tanaka(University of Oxford), Taku Tanaka(University of Oxford), Hayato Taniguchi(University of Oxford), Coralie Tardivon(University of Oxford), Pierre Tattevin(University of Oxford), M Azhari Taufik(University of Oxford), Richard S. Tedder(University of Oxford), João Teixeira(University of Oxford), Marie-Capucine Tellier(University of Oxford), Pleun Terpstra(University of Oxford), Olivier Terrier(University of Oxford), Nicolas Terzi(University of Oxford), Hubert Tessier-Grenier(University of Oxford), Vincent Thibault(University of Oxford), Simon-Djamel Thiberville(University of Oxford), Benoît Thill(University of Oxford), A. A. Roger Thompson(University of Oxford), Shaun Thompson(University of Oxford), David Thomson(University of Oxford), Emma C. Thomson(University of Oxford), Duong Bich Thuy(University of Oxford), Ryan S. Thwaites(University of Oxford), Peter Timashev(University of Oxford), Jean-François Timsit(University of Oxford), Bharath Kumar Tirupakuzhi Vijayaraghavan(University of Oxford), Maria Toki(University of Oxford), Kristian Tonby(University of Oxford), Rosario María Torres Santos-Olmo(University of Oxford), Antoni Torres(University of Oxford), Margarida Torres(University of Oxford), Théo Trioux(University of Oxford), Huynh Trung Trieu(University of Oxford), Cécile Tromeur(University of Oxford), Ioannis P. Trontzas(University of Oxford), Jonathan P. Troost(University of Oxford), Tiffany Trouillon(University of Oxford), Christelle Tual(University of Oxford), Sarah Tubiana(University of Oxford), Helen Tuite(University of Oxford), Lance Turtle(University of Oxford), Paweł Twardowski(University of Oxford), Makoto Uchiyama(University of Oxford), Roman Ullrich(University of Oxford), Alberto Uribe(University of Oxford), Asad Usman(University of Oxford), Luís Val-Flores(University of Oxford), Stijn Van de Velde(University of Oxford), Marcel van den Berge(University of Oxford), M. van der Feltz(University of Oxford), Nicky Van Der Vekens(University of Oxford), Peter Van der Voort(University of Oxford), Sylvie van der Werf(University of Oxford), Marlice van Dyk(University of Oxford), Laura van Gulik(University of Oxford), Jarne Van Hattem(University of Oxford), Steven Van Lelyveld(University of Oxford), Carolien van Netten(University of Oxford), Noémie Vanel(University of Oxford), Henk Vanoverschelde(University of Oxford), Charline Vauchy(University of Oxford), Aurélie Veislinger(University of Oxford), Jorge Velazco(University of Oxford), Sara Ventura(University of Oxford), Annelies Verbon(University of Oxford), César Vieira(University of Oxford), Joy Ann Villanueva(University of Oxford), Judit Villar(University of Oxford), Pierre-Marc Villeneuve(University of Oxford), Andrea Villoldo(University of Oxford), Nguyễn Văn Vĩnh Châu(University of Oxford), Benoît Visseaux(University of Oxford), Hannah Visser(University of Oxford), Aapeli Vuorinen(University of Oxford), Fanny Vuotto(University of Oxford), Chih‐Hsien Wang(University of Oxford), Jia Wei(University of Oxford), Katharina Weil(University of Oxford), Sanne Wesselius(University of Oxford), Murray Wham(University of Oxford), Bryan Whelan(University of Oxford), Nicole White(University of Oxford), Aurélie Wiedemann(University of Oxford), Keith Wille(University of Oxford), Evert‐Jan Wils(University of Oxford), Ioannis Xynogalas(University of Oxford), Jacky Y. Suen(University of Oxford), Sophie Yacoub(University of Oxford), Masaki Yamazaki(University of Oxford), Yazdan Yazdanpanah(University of Oxford), Cécile Yelnik(University of Oxford), Stephanie T. Yerkovich(University of Oxford), Toshiki Yokoyama(University of Oxford), Hodane Yonis(University of Oxford), Paul J. Young(University of Oxford), Saptadi Yuliarto(University of Oxford), Marion Zabbe(University of Oxford), Kai Zacharowski(University of Oxford), Maram Zahran(University of Oxford), Maria Zambon(University of Oxford), Alberto Zanella(University of Oxford), Konrad Zawadka(University of Oxford), Hiba Zayyad(University of Oxford), Alexander Zoufaly(University of Oxford), David Zucman(University of Oxford)
Cited by 80Open Access
Abstract
BACKGROUND: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. METHODS: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. RESULTS: 'Typical' symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. INTERPRETATION: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
Related Papers
No related papers found
Powered by citation graph analysis