ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Jiehui Deng; Aatish Thennavan; Igor Dolgalev; Ting Chen; Jie Li; Antonio Marzio; John T. Poirier; David H. Peng; Mirna Bulatović; Subhadip Mukhopadhyay; Heather Silver; Eleni Papadopoulos; Val Pyon; Cassandra Thakurdin; Han Han; Fei Li; Shuai Li; Hailin Ding; Hai Hu; Yuanwang Pan; Vajira Weeresekara; Baishan Jiang; Eric S. Wang; Ian M. Ahearn; Mark R. Philips; Thales Papagiannakopoulos; Aristotelis Tsirigos; Eli Rothenberg; Justin F. Gainor; Gordon J. Freeman; Charles M. Rudin; Nathanael S. Gray; Peter S. Hammerman; Michele Pagano; John V. Heymach; Charles M. Perou; Nabeel Bardeesy; Kwok‐Kin Wong

doi:10.1038/s43018-021-00208-6

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Jiehui Deng(NYU Langone Health), Aatish Thennavan(University of North Carolina at Chapel Hill), Igor Dolgalev(NYU Langone Health), Ting Chen(NYU Langone Health), Jie Li(NYU Langone Health), Antonio Marzio(NYU Langone Health), John T. Poirier(Memorial Sloan Kettering Cancer Center), David H. Peng(NYU Langone Health), Mirna Bulatović(NYU Langone Health), Subhadip Mukhopadhyay(New York University), Heather Silver(NYU Langone Health), Eleni Papadopoulos(NYU Langone Health), Val Pyon(NYU Langone Health), Cassandra Thakurdin(NYU Langone Health), Han Han(NYU Langone Health), Fei Li(NYU Langone Health), Shuai Li(NYU Langone Health), Hailin Ding(NYU Langone Health), Hai Hu(NYU Langone Health), Yuanwang Pan(NYU Langone Health), Vajira Weeresekara(Harvard University), Baishan Jiang(Harvard University), Eric S. Wang(Harvard University), Ian M. Ahearn(New York University), Mark R. Philips(New York University), Thales Papagiannakopoulos(NYU Langone Health), Aristotelis Tsirigos(NYU Langone Health), Eli Rothenberg(New York University), Justin F. Gainor(Massachusetts General Hospital), Gordon J. Freeman(Harvard University), Charles M. Rudin(Memorial Sloan Kettering Cancer Center), Nathanael S. Gray(Stanford University), Peter S. Hammerman(Harvard University), Michele Pagano(Howard Hughes Medical Institute), John V. Heymach(The University of Texas MD Anderson Cancer Center), Charles M. Perou(University of North Carolina at Chapel Hill), Nabeel Bardeesy(Harvard University), Kwok‐Kin Wong(NYU Langone Health)

Nature Cancer

May 17, 2021

10.1038/s43018-021-00208-6

Cited by 136Open Access

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