A polysaccharide from natural <i>Cordyceps sinensis</i> regulates the intestinal immunity and gut microbiota in mice with cyclophosphamide-induced intestinal injury
Shuping Chen(Nanchang University), Junqiao Wang(Nanchang University), Qiuyue Fang(Nanchang University), Nan Dong(Nanchang University), Qingying Fang(Nanchang University), Steve W. Cui(Agriculture and Agri-Food Canada), Shaoping Nie(Nanchang University)
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Abstract
T cells, stimulate the secretion of interleukins (IL)-17 and IL-21, and the expression of transcription factor (retinoic acid-related orphan receptor (ROR)-γt). The levels of transforming growth factor (TGF)-β3 and transcription factor (forkhead box (Fox)p-3) were increased in NCSP-treated groups. Moreover, NCSP upregulated the mRNA expression of toll like receptors (TLR-2, -6 and -9), while it downregulated the TLR-4 expression. In addition, NCSP modulated the intestinal microbiota composition and increased the levels of SCFAs. These findings indicated that NCSP may enhance intestinal immunity and have the potential to become a prebiotic to regulate intestinal microbiota.
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