SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
Artem Nemudryi(Montana State University), Anna Nemudraia(Montana State University), Tanner Wiegand(Montana State University), Joseph Nichols(Montana State University), Deann T. Snyder(Montana State University), Jodi F. Hedges(Montana State University), Calvin Cicha(Montana State University), Helen Lee(Montana State University), Karl K. Vanderwood(Lake County), Diane Bimczok(Montana State University), Mark A. Jutila(Montana State University), Blake Wiedenheft(Montana State University)
Cited by 85Open Access
Abstract
) to a growth defect. ORF7a is implicated in immune modulation, and we show that the C-terminal truncation negates anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently, and that these changes affect viral mechanisms responsible for suppressing the immune response.
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