GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
David Aguilar-Recarte(Hospital Sant Joan de Déu Barcelona), Emma Barroso(Hospital Sant Joan de Déu Barcelona), Anna Gumà(Instituto de Salud Carlos III), Javier Pizarro‐Delgado(Hospital Sant Joan de Déu Barcelona), Lucía Peña(Hospital Sant Joan de Déu Barcelona), Maria Ruart(Hospital Sant Joan de Déu Barcelona), Xavier Palomer(Hospital Sant Joan de Déu Barcelona), Walter Wahli(Nanyang Technological University), Manuel Vázquez‐Carrera(Hospital Sant Joan de Déu Barcelona)
Cited by 109Open Access
Abstract
mice show reduced AMPK activation in skeletal muscle, whereas GDF15 administration results in AMPK activation in this organ. Collectively, these data reveal a mechanism by which PPARβ/δ activation increases GDF15 levels via AMPK and p53, which in turn mediates the metabolic effects of PPARβ/δ by sustaining AMPK activation.
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