Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis
Anastasiia Grigoreva(Skolkovo Institute of Science and Technology), Julia Andreeva(Skolkovo Institute of Science and Technology), Dmitry Bikmetov(Institute of Gene Biology), Anastasiia Rusanova(Institute of Gene Biology), Marina V. Serebryakova(Lomonosov Moscow State University), Andrea Hernandez Garcia(University of Illinois Urbana-Champaign), Darya Slonova(Skolkovo Institute of Science and Technology), Satish K. Nair(University of Illinois Urbana-Champaign), Guy Lippens(Centre National de la Recherche Scientifique), Konstantin Severinov(Skolkovo Institute of Science and Technology), Svetlana Dubiley(Skolkovo Institute of Science and Technology)
Cited by 35Open Access
Abstract
. Members of the family are distinguished by the presence of a single carboxy-terminal labionin. We identified and characterized andalusicin, a representative of this family. Andalusicin bears two methyl groups at the α-amino terminus, a post-translational modification that has not previously been identified in class III lanthipeptides. Mature andalusicin A shows bioactivity against various Gram-positive bacteria, an activity that is highly dependent on the α-N dimethylation.
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