Polysaccharide MCP extracted from <i>Morchella esculenta</i> reduces atherosclerosis in LDLR-deficient mice

Dandan Wang(Hefei University of Technology), Zequn Yin(Hefei University of Technology), Likun Ma(University of Science and Technology of China), Lan Han(Anhui University of Traditional Chinese Medicine), Yan Chen(Anhui University), Wen‐Juan Pan(Anhui University), Ke Gong(Hefei University of Technology), Yongyao Gao(Hefei University of Technology), Xiaoxiao Yang(Hefei University of Technology), Yuanli Chen(Anhui University), Jihong Han(Hefei University of Technology), Yajun Duan(Hefei University of Technology)
Food & Function
January 1, 2021
10.1039/d0fo03475d
Cited by 39

Abstract

) mice were fed high-fat diet (HFD) and administered intragastrically (i.g.) with saline or MCP dissolved in saline for 15 weeks. We found that MCP inhibited en face and sinus lesions. Moreover, serum levels of total and low-density lipoprotein cholesterol and triglyceride were decreased by MCP. The HFD-induced hepatic lipid accumulation was also attenuated by MCP. The underlying molecular mechanisms of anti-atherogenic and lipogenic effects of MCP might be attributed to reduced cholesterol synthesis by activating AMPKα signaling pathway and inhibiting SREBP2 expression. In addition, MCP-decreased serum triglyceride level is related to inhibiting LXRα expression. Taken together, these results indicate that MCP markedly alleviates atherosclerosis and M. esculenta can be used as a functional food additive to benefit patients with atherosclerosis.

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